局部窄谱中波紫外线联合地奈德乳膏治疗儿童中重度特应性皮炎的疗效观察

doi:10.3969/j.issn.1674-8115.2026.01.016

上海交通大学学报（医学版） ›› 2026, Vol. 46 ›› Issue (1): 132-136.doi: 10.3969/j.issn.1674-8115.2026.01.016

• 短篇论著 • 上一篇

局部窄谱中波紫外线联合地奈德乳膏治疗儿童中重度特应性皮炎的疗效观察

万朋杰¹^,², 杨绍芳², 齐珺²()

^1.上海交通大学医学院附属上海儿童医学中心皮肤科，上海 200127
^2.上海交通大学医学院附属上海儿童医学中心贵州医院儿童皮肤科，贵阳 550081

收稿日期:2025-06-17 接受日期:2025-09-08 出版日期:2026-01-28 发布日期:2026-01-30
通讯作者: 齐　珺，副主任医师，学士；电子信箱：2261854635@qq.com。
作者简介:第一联系人：万朋杰负责收集样本、设计研究方案、撰写文章，对论文整体负责，杨绍芳负责收集样本、统计分析、撰写文章，齐珺负责研究方案实施、修改文章。所有作者均阅读并同意了最终稿件的提交。
基金资助:
国家自然科学基金(82203910);贵州省卫生健康委课题(2025GZWJKJXM1921);上海申康医院发展中心诊疗技术推广及优化管理项目(SHDC22025306)

Efficacy of topical narrow-band ultraviolet B combined with desonide cream in children with moderate-to-severe atopic dermatitis

Wan Pengjie¹^,², Yang Shaofang², Qi Jun²()

^1.Department of Dermatology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
^2.Department of Pediatric Dermatology, Shanghai Children's Medical Center Guizhou Hospital, Shanghai Jiao Tong University School of Medicine, Guiyang 550081, China

Received:2025-06-17 Accepted:2025-09-08 Online:2026-01-28 Published:2026-01-30
Contact: Qi Jun, E-mail: 2261854635@qq.com.
About author:First author contact:Wan Pengjie was responsible for sample collection, study design, article writing, and overall responsibility for the paper. Yang Shaofang was responsible for sample collection, statistical analysis, and article writing. Qi Jun was responsible for the implementation of the research plan and manuscript revision. All authors have read the last version of paper and consented to its submission.
Supported by:
National Natural Science Foundation of China(82203910);Guizhou Provincial Health Commission Program(2025GZWJKJXM1921);Clinical Research Plan of Shanghai Shenkang Hospital Development Center(SHDC22025306)

摘要/Abstract

摘要：

目的·探讨局部窄谱中波紫外线（narrow-band ultraviolet B，NB-UVB）联合地奈德乳膏治疗儿童中重度特应性皮炎（atopic dermatitis，AD）的临床疗效及安全性，为临床治疗提供优化方案。方法·选取上海交通大学医学院附属上海儿童医学中心及其贵州分院皮肤科收治的166例中重度AD患儿，根据不同治疗方案分为实验组（n=86）和对照组（n=80）。对照组采用地奈德乳膏外用联合基础润肤治疗，实验组在对照组基础上增加局部NB-UVB照射（每周2次，起始剂量0.2 J/cm²，按需调整）。比较2组患儿治疗2、4周后的特应性皮炎评分（SCORing Atopic Dermatitis，SCORAD）、瘙痒视觉模拟评分（Visual Analogue Scale for Pruritus，VAS），随访8周的复发率及治疗期间不良反应发生情况。结果·治疗4周后，实验组SCORAD及VAS均较对照组显著下降（P<0.001，P=0.017）；实验组总有效率为90.7%（78/86），显著高于对照组的76.3%（61/80）（χ²=6.210，P=0.012）。随访8周，实验组复发率为11.5%（9/78），低于对照组的24.6%（15/61）（χ²=4.082，P=0.043）。实验组不良反应发生率为7.0%（6/86），主要表现为轻度红斑、皮肤色素减退等；对照组为3.8%（3/80），以毛囊炎、皮肤色素减退为主；2组比较差异无统计学意义，且均未出现严重不良反应。结论·局部NB-UVB联合地奈德乳膏治疗儿童中重度AD疗效确切，能快速缓解皮损症状及瘙痒程度，显著降低复发率，且安全性良好，未增加严重不良反应风险，为儿童中重度AD的临床治疗提供了更优选择，值得推广应用。

关键词: 窄谱中波紫外线, 特应性皮炎, 儿童, 地奈德乳膏, 光疗

Abstract:

Objective ·To investigate the clinical efficacy and safety of topical narrow-band ultraviolet B (NB-UVB) combined with desonide cream in the treatment of moderate-to-severe atopic dermatitis (AD) in children and to provide an optimized regimen for clinical practice. Methods ·A total of 166 children with moderate-to-severe AD admitted to the Department of Dermatology, Shanghai Children′s Medical Center, Shanghai Jiao Tong University School of Medicine and its Guizhou Branch were enrolled. They were divided into an experimental group (86 cases) and a control group (80 cases) according to different treatment regimens. The control group was treated with topical desonide cream combined with basic emollient therapy, while the experimental group received additional topical NB-UVB irradiation on the basis of the control group′s regimen (twice weekly, initial dose of 0.2 J/cm², adjusted as needed). The SCORing Atopic Dermatitis (SCORAD) index and Visual Analogue Scale for Pruritus (VAS) scores of the two groups were compared after 2 and 4 weeks of treatment, as well as the recurrence rate during the 8-week follow-up and the incidence of adverse reactions during treatment. Results ·After 4 weeks of treatment, both SCORAD and VAS scores in the experimental group were significantly lower than those in the control group (P<0.001, P=0.017); the total effective rate of the experimental group was 90.7% (78/86), which was significantly higher than that of the control group [76.3% (61/80); χ²=6.210, P=0.012]. During the 8-week follow-up, the recurrence rate in the experimental group was 11.5% (9/78), which was lower than that in the control group [24.6% (15/61); χ²=4.082, P=0.043]. The incidence of adverse reactions in the experimental group was 7.0% (6/86), mainly mild erythema and hypopigmentation, whereas that in the control group was 3.8% (3/80), mainly folliculitis and hypopigmentation. There was no statistically significant difference between the two groups, and no severe adverse reactions occurred in either group. Conclusion ·Topical NB-UVB combined with desonide cream has a definite efficacy in the treatment of moderate-to-severe AD in children. It can rapidly resolve skin lesions and alleviate pruritus, significantly reduce the recurrence rate, and does not increase the risk of severe adverse reactions. It provides a better option for the clinical treatment of moderate-to-severe AD in children, and is worthy of wide clinical promotion and application.

Key words: narrow-band ultraviolet B (NB-UVB), atopic dermatitis (AD), child, desonide cream, phototherapy

中图分类号:

R758.2

万朋杰, 杨绍芳, 齐珺. 局部窄谱中波紫外线联合地奈德乳膏治疗儿童中重度特应性皮炎的疗效观察[J]. 上海交通大学学报（医学版）, 2026, 46(1): 132-136.

Wan Pengjie, Yang Shaofang, Qi Jun. Efficacy of topical narrow-band ultraviolet B combined with desonide cream in children with moderate-to-severe atopic dermatitis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026, 46(1): 132-136.

图/表 3

图1 2组患儿治疗前与治疗2、4周的SCORAD比较Note： ①P=0.667, ②P=0.164, ③P<0.001.

Fig 1 Comparison of SCORAD scores before treatment and at 2 and 4 weeks after treatment between the two groups

图2 2组患儿治疗前与治疗2、4周的VAS比较Note： ①P=0.633, ②P=0.433, ③P=0.017.

Fig 2 Comparison of VAS scores before treatment and at 2 and 4 weeks after treatment between the two groups

表1 2组患儿临床疗效比较

Tab 1 Comparison of clinical efficacy between the two groups

Group	Number of cases/n	Recovered/n(%)	Markedly improved/n(%)	Improved/n(%)	Ineffective/n(%)	Total effective rate^①/n(%)
Experimental group	86	35(40.7)	43(50.0)	6(7.0)	2(2.3)	78(90.7)
Control group	80	22(27.5)	39(48.8)	14(17.5)	5(6.3)	61(76.3)

参考文献 11

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局部窄谱中波紫外线联合地奈德乳膏治疗儿童中重度特应性皮炎的疗效观察

Efficacy of topical narrow-band ultraviolet B combined with desonide cream in children with moderate-to-severe atopic dermatitis

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