上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 论著（预防医学） • 上一篇    下一篇

室内杀虫剂暴露与儿童急性白血病发病的关系

陈迪迪，张 妍，施 蓉，田 英，季晓帆，韩开益，胡诗尧，茅淑倩，冯婧顗，高 宇   

  1. 上海交通大学 公共卫生学院环境卫生学教研室， 上海 200025
  • 出版日期:2014-02-28 发布日期:2014-03-25
  • 通讯作者: 高 宇, 电子信箱: gaoyu999@hotmail.com。
  • 作者简介:陈迪迪（1989—）， 女， 硕士生; 电子信箱: chendidi_1989@163.com。
  • 基金资助:
    国家自然科学基金（30901171），上海市自然科学基金（09ZR1416500），上海市卫生局重点学科建设项目（12GWZX0401），上海交通大学医学院基金（12XJ10006和12XJ10043）

Exposure to household insecticides and risk of childhood acute leukemia

CHEN Di-di, ZHANG Yan, SHI Rong, TIAN Ying, JI Xiao-fan, HAN Kai-yi, HU Shi-yao, MAO Shu-qian, FENG Jing-yi, GAO Yu   

  1. Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2014-02-28 Published:2014-03-25
  • Supported by:
    National Natural Science Foundation of China，30901171； Natural Science Foundation of Shanghai，09ZR1416500； Key Discipline Construction
    Project of Shanghai Municipal Health Bureau，12GWZX0401； Shanghai Jiao Tong University School of Medicine Foundation，12XJ10006 and 12XJ10043

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摘要：

目的 探讨儿童不同发育时期室内杀虫剂暴露与儿童急性白血病（AL）发病的关系。方法 通过社区匹配方式对病例组和经性别、年龄、居住地匹配得到的对照组的儿童父母/监护人进行面对面的访谈式调查，获取研究对象的一般人口学特征及儿童不同发育时期室内杀虫剂使用情况，对调查结果进行条件Logistic回归分析，计算OR值和95%CI。结果 病例组家庭室内杀虫剂的使用率高于对照组家庭，主要使用的杀虫剂种类为驱蚊剂和灭蟑螂剂。在儿童0～3岁期间，室内杀虫剂的使用（OR=6.3，95%CI：1.4，28.7）、灭蟑螂剂的使用（OR=7.8，95%CI：1.6，37.7）和在最近1年内驱蚊剂的使用（OR=3.3，95%CI：1.1，10.2）都有可能增加儿童患AL的危险。另外，在儿童0～3岁期间，随着驱蚊剂使用频率的增加（OR=5.8，95%CI：1.1，30.1）和灭蟑螂剂使用频率的增加（OR=8.9，95%CI：1.5，52.2），儿童患AL的危险性增加。结论 在儿童0～3岁期间和最近1年内室内杀虫剂暴露有可能增加儿童患AL的危险。

关键词: 儿童, 急性白血病, 农药, 病例-对照研究, 上海

Abstract:

Objective To investigate the relationship between household insecticides exposure and the incidence of childhood acute leukemia (AL) for different development periods of children. Methods We interviewed parents/guardians of children from case group and control group which matched the case group with respect to gender, age, and location of residence. Information on normal sociodemographic characteristics of subjects and household insecticides usage during their different development periods was collected. The results of investigation were processed by conditional logistic regression analysis and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results The rate of household insecticides usage of case group was higher than that of the control group. Mainly used insecticides were mosquito repellent and cockroach killer. The incidence of childhood AL may increase when household insecticides were used (OR=6.3, 95%CI: 1.4-28.7) and cockroach killer was used (OR=7.8, 95%CI: 1.6-37.7) during the period of 0-3 years old, and mosquito repellent was used (OR=3.3, 95%CI: 1.1-10.2) during the most resent year. Besides, the incidence of childhood AL might also increase when the usage frequency of mosquito repellent (OR=5.8, 95%CI: 1.1, 30.1) and cockroach killer (OR=8.9, 95%CI: 1.5, 52.2) increased. Conclusion Household insecticides exposure during the period of 0-3 years old
and the most resent year may increase the risk of childhood AL.

Key words: children, acute leukemia, pesticide, case-control study, Shanghai