上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2015, Vol. 35 ›› Issue (10): 1550-.doi: 10.3969/j.issn.1674-8115.2015.10.024

• 综述 • 上一篇    下一篇

双相障碍与代谢综合征关系的研究进展

向慧，汪作为，方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科， 上海200030
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 方贻儒, 电子信箱: yirufang@aliyun.com
  • 作者简介:向慧（1991—）， 女， 博士生; 电子信箱: 452095746@qq.com
  • 基金资助:

    国家自然科学基金（91232719）；科技部“十二五”国家科技支撑项目（2012BAI01B04）；国家临床重点专科-上海市精神卫生中心（卫生部医政司2011-873）

Advances of metabolic syndrome in patients with bipolar disorders

XIANG Hui, WANG Zuo-wei, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China， 91232719； National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-year Plan”， 2012BAI01B04； National Key Clinical Disciplines at Shanghai Mental Health Center， OMA-MH 2011-873

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摘要：

代谢综合征（MS）是由于胰岛素抵抗引发的个体一系列临床、生化、体液代谢异常，从而引起多种物质代谢失常的综合征。目前MS与双相障碍(BD)的关联性尚不明确，不良的生活方式、神经内分泌及免疫系统异常、遗传易感性都可能起着一定作用，而精神药物治疗的不良反应也可能是导致患病率增加的重要因素。众多研究显示MS在BD患者中出现的风险显著高于普通人群，且是BD不良预后的主要原因之一，因此治疗BD时预防MS愈发重要。该文综述了BD患者与MS关系的流行病学、病理机制、预防及处理等方面的研究进展。

关键词: 代谢综合征, 双相障碍, 肥胖, 糖尿病

Abstract:

Metabolic syndrome (MS) has been identified as a series of insulin resistance-caused clinical, biochemical, and humoral metabolic abnormalities, which result in metabolic abnormalities of many matters. The correlation between MS and bipolar disorder (BD) is still unclear. The side effects of psychotropic medications may be major contributors to the increased incidence of MS of patients with BD. Other factors such as unhealthy lifestyle, neuroendocrine and immunoinflammatory abnormalities, and genetic vulnerability may also play a role. Many studies show that the risk of incidence of MS of patients with BD is significantly higher than that of general population and is a major reason for poor prognosis of BD, which indicate that prevention of MS for the treatment of BD is important. This paper reviews research advances of epidemiology, pathophysiological mechanisms, prevention, and treatment of MS for patients with BD.

Key words: metabolic syndrome, bipolar disorder, obesity, diabetes mellitus