上海交通大学学报（医学版）

上海交通大学学报（医学版）

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白假丝酵母菌唑类耐药相关的转录调控研究进展

刘锦燕1，史册2，王影2，李文静2，赵悦2，朱巍巍1，项明洁1,2   

  1. 1.上海交通大学  医学院附属瑞金医院卢湾分院放免检验科， 上海 200020； 2.上海交通大学 医学院附属瑞金医院检验科， 上海 200025
  • 出版日期:2016-02-28 发布日期:2016-03-29
  • 通讯作者: 项明洁, 电子信箱: mjxiang123456@126.com。
  • 作者简介:刘锦燕（1981—）， 女， 主管技师， 硕士; 电子信箱: stellaljy@163.com。
  • 基金资助:

    上海市重点专科配套课题（ZK2012A21）；上海市科委基金（15ZR1426900）；上海黄浦区卫生局基金（2012-HGG-44）；上海市黄浦区卫生系统优秀青年人才培养计划（RCPY1407)

Research advances in transcription regulation related to azole resistance of Candida albicans

LIU Jin-yan1, SHI Ce2, WANG Ying2, LI Wen-jing2, ZHAO Yue2, ZHU Wei-wei1, XIANG Ming-jie1,2   

  1. 1.Department of Clinical Laboratory, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China; 2.Department of Clinical Laboratory; Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-02-28 Published:2016-03-29
  • Supported by:

    Project of Shanghai Key Specialty, ZK2012A21; Foundation of Shanghai Municipal Science and Technology Commission, 15ZR1426900; Foundation of Shanghai Municipal Huangpu District Health Bureau, 2012-HGG-44; Shanghai Municipal Huangpu District Health System Program for Youths, RCPY1407

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摘要：

近30年来，白假丝酵母菌已成为导致免疫功能低下患者发病和死亡最常见的条件致病性真菌。随着临床上唑类药物的频繁使用，耐药菌株不断被检出，其耐药机制研究也备受关注。近年来，其在转录调控水平的机制研究也取得了很大进展，明确了耐药相关编码基因的顺式作用元件和反式作用因子，并部分阐述了相应的作用机制。文章就白假丝酵母菌唑类药物耐药相关的转录调控研究进展作一综述。

关键词: 白假丝酵母菌, 转录调控, 外排泵, 靶酶, 顺式作用元件, 反式作用因子

Abstract:

In recent 30 years, Candida albicans has become the most common opportunistic pathogen that causes the incidence and mortality of patients with low immunity. With the frequent use of azole antifungal drugs, azole-resistant strains are often detected. Studies on the mechanism of drug resistance have drawn more and more attention. In recent years, studies on the mechanism of transcriptional regulation have also made great progress. The cis-acting elements and trans-acting factors of the resistant-related encoding gene were identified and the acting mechanism was partially elucidated. In this paper, research advances in the transcription regulation related to azole resistance of Candida albicans are reviewed.

Key words: Candida albicans, transcriptional regulation, efflux pump, target enzyme, cis-acting regulatory elements, trans-acting factors