上海交通大学学报（医学版）

上海交通大学学报（医学版）

• 综述 • 上一篇    下一篇

砷与糖尿病发生的关系及砷致糖代谢紊乱的机制研究进展

孙洪林，陆颖理   

  1. 上海交通大学 医学院附属第九人民医院内分泌代谢科， 上海 200011
  • 出版日期:2016-07-28 发布日期:2016-08-31
  • 通讯作者: 陆颖理, 电子信箱: luyingli2008@126.com。
  • 作者简介:孙洪林（1991—）， 女， 硕士生; 电子信箱: sylinsun@163.com。
  • 基金资助:

    上海科委长三角科技攻关课题（14495810700）

Research advances in the association between arsenic and the incidence of diabetes mellitus and the mechanisms of glucose metabolic disorders caused by arsenic

SUN Hong-lin, LU Ying-li   

  1. Department of Endocrinology and Metabolism, the Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2016-07-28 Published:2016-08-31
  • Supported by:

    Project of Science and Technology Commission of Shanghai Municipality， 14495810700

PDF (PC)

970

摘要：

近年来，环境因素在糖尿病发生和发展过程中所起的作用受到越来越多的重视，很多证据表明砷暴露与糖尿病的发生存在密切联系。在世界各地饮水砷污染地区，糖尿病的发病率显著升高。越来越多的细胞和动物实验也证实，不同浓度的砷化合物可以引起胰岛素抵抗与外周组织葡萄糖摄取障碍，从而引发糖耐量异常。文章主要从流行病学研究以及发病机制两方面阐述砷暴露与糖尿病的发生关系。

关键词: 砷, 糖尿病, 流行病学, 发病机制

Abstract:

The role of environmental factors in the occurrence and development of diabetes mellitus has drawn more and more attention in recent years. A large amount of evidence has suggested a close association between arsenic exposure and the incidence of diabetes. The incidence of diabetes increases significantly in areas that drinking water is polluted by arsenic. More and more cell and animal experiments have indicated that arsenide can result in insulin resistance and impaired glucose uptake in peripheral tissues, which can cause impaired glucose tolerance. The paper reviews the association between arsenic exposure and the incidence of diabetes from perspectives of epidemiological study and pathogenesis.

Key words: arsenic, diabetes mellitus, epidemiology, pathogenesis