上海交通大学学报（医学版）

上海交通大学学报（医学版）

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金黄色葡萄球菌ESAT-6分泌系统研究进展

王亚楠 李敏   

  1. 上海交通大学 医学院附属仁济医院检验科，上海 200127
  • 出版日期:2016-08-29 发布日期:2016-08-31
  • 作者简介:王亚楠（1990—），女，检验技师，硕士；电子信箱：wangyn0819@126.com。
  • 基金资助:

    国家自然科学基金（81322025，81371875）；上海曙光人才计划（12SG03）；上海市科学技术委员会基金（14140901000，15411960500）；上海市教育委员会高峰高原学科建设计划（20152513）

Research advances in ESAT-6 secretion system in Staphylococcus aureus

WANG Ya-nan, LI Min   

  1. Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-08-29 Published:2016-08-31
  • Supported by:

    National Natural Science Foundation of China, 81322025, 81371875; Shanghai Shuguang Talent Project, 12SG03; Foundation of Shanghai Municipal Science and Technology Committee, 14140901000, 15411960500; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152513

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摘要：

金黄色葡萄球菌是临床重要的致病菌，引起的感染可以累及全身各脏器，严重威胁人类健康。ESAT-6分泌系统广泛存在于革兰阳性菌。在金黄色葡萄球菌中，经典的ESAT-6通路由esxA、esxB及其他9个分子组成的基因簇构成，该系统分泌的ESAT-6/WXG100家族蛋白对金黄色葡萄球菌的毒力和免疫防御功能起到重要作用。该文就金黄色葡萄球菌ESAT-6分泌系统的研究进展进行综述。

关键词: 金黄色葡萄球菌, ESAT-6分泌系统, 毒力

Abstract:

Staphylococcus aureus is an important opportunistic pathogen that causes a variety of infections, which can involve all organs in the body and seriously threat people’s health. The ESAT-6 secretion system widely exists in gram-positive bacteria. Typical ESAT-6 pathway is composed of a gene cluster consisting of esxA, esxB, and nine other molecules in Staphylococcus aureus. ESAT-6/WXG100 protein family secreted by this system plays a critical role in virulence and protective immunity of Staphylococcus aureus. This article reviews research advances in ESAT-6 secretion system in Staphylococcus aureus.

Key words: Staphylococcus aureus, ESAT-6 secretion system, virulence