上海交通大学学报(医学版) ›› 2018, Vol. 38 ›› Issue (6): 632-.doi: 10.3969/j.issn.1674-8115.2018.06.008

• 论著·临床研究 • 上一篇    下一篇

分化型甲状腺癌患者碘治疗前肝功能、血脂及血常规水平变化

许飞,汤玲琳,袁红,宋少莉 ,黄钢   

  1. 上海交通大学医学院附属仁济医院核医学科,上海 200127
  • 出版日期:2018-06-28 发布日期:2018-07-03
  • 通讯作者: 宋少莉,电子信箱:shaoli-song@163.com。黄钢,电子信箱:huang2802@163.com。为共同通信作者。
  • 作者简介:许飞(1992—),女,博士生;电子信箱:renjixufei@163.com。
  • 基金资助:
    国家自然科学基金 (81771861, 81471708);上海市教育委员会高峰高原学科建设计划(20172010)

Analysis of liver function, serum lipid and blood routine in patients with differentiated thyroid cancer before radioactive iodine treatment

XU Fei, TANG Ling-lin, YUAN Hong, SONG Shao-li, HUANG Gang   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China, 81771861, 81471708; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20172010

摘要: 目的·观察分化型甲状腺癌(differentiated thyroid cancer,DTC)患者在停用左旋甲状腺激素所致的一过性甲状腺功能减退(简称甲减)状态下肝功能、血脂及血常规的变化。方法·收集行甲状腺癌根治术及131I治疗的182例患者术前(甲状腺功能正常)和术后甲减状态(停用甲状腺素3~ 4周,促甲状腺激素 > 30 mU/L)的肝功能、血常规、血脂等测定结果。将患者按照年龄分为3组:青年组(< 30岁)26例,中年组(30~ 54岁)112例,老年组(≥ 55岁)44例。比较手术前后以及不同组别患者各项指标的差异。结果·碘治疗前甲减状态下患者的谷丙转氨酶、谷草转氨酶、乳酸脱氢酶及胆汁酸均有升高(均P<0.05),而血清直接胆红素和总胆红素水平出现下降(均P<0.05),三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白升高(均P<0.05),红细胞与血红蛋白轻度升高。青年组碘治疗前甲减状态下,谷丙转氨酶、谷草转氨酶、乳酸脱氢酶、胆汁酸升高较中年组及老年组更为显著(均P<0.05)。结论· DTC患者停用左旋甲状腺激素所致的一过性甲减状态会引起肝酶异常、血脂水平升高,临床工作中需予以重视。

关键词: 分化型甲状腺癌, 放射性碘, 肝功能异常, 甲状腺功能减退

Abstract:

Objective · To investigate the effect of temporary hypothyroidism state to liver function, serum lipid and blood routine in patients with differentiated thyroid cancer (DTC) prepared for radioactive iodine treatment. Methods · A total of 182 patients with DTC undergoing radical operation of thyroid cancer and radioactive iodine treatment were collected. All these patients were divided into 3 groupsage: 26 in young group (<30 years), 112 in middle-aged group (30-54 years) and 44 in elderly group (≥55 years). Indicators of liver function, blood lipids and blood routine were compared before and after operation, among groups as well. Results · Patients under hypothyroidism state had significantly elevations in ALT, AST, LDH and serum bile acid, but a nodecrease of serum bilirubin (all P<0.05). Meanwhile they had remarkable elevations in triglyceride, cholesterol, LDL and HDL (all P<0.05). In the young group before thyroid hypothyroidism treatment, the elevation of ALT, AST, LDH and serum bile acid were more significant than those of the middle-aged and elderly patients (all P<0.05). Conclusion · The temporary hypothyroidism state of differentiated thyroid cancer patients could elevate liver enzymes as well as dyslipidemia.

Key words: differentiated thyroid cancer, iodine radioisotopes, liver dysfunction, hypothyroidism

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