上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (6): 655-.doi: 10.3969/j.issn.1674-8115.2019.06.015

• 综述 • 上一篇    下一篇

重复经颅磁刺激调控物质成瘾相关神经环路的研究进展

许晓敏，陈天真，江海峰   

  1. 上海交通大学医学院附属精神卫生中心物质依赖科，上海 200030
  • 出版日期:2019-06-28 发布日期:2019-07-26
  • 通讯作者: 江海峰，电子信箱：dragonjhf@hotmail.com。
  • 作者简介:许晓敏（1995—），女，硕士生；电子信箱： xuxiaomin0801@163.com。
  • 基金资助:
    国家自然科学基金青年科学基金（81601164）；上海市“科技创新行动计划”医学引导项目（18411961200）；上海市卫生系统优秀人才培养计划（2017YQ013）；上海市精神卫生中心“飞翔计划” (2016-FX-003)；上海交通大学医学院多中心临床研究项目（DLY201818）

Modulating neural circuits in substance addiction with repetitive transcranial magnetic stimulation

XU Xiao-min, CHEN Tian-zhen, JIANG Hai-feng   

  1. Department of Drug Dependence, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-06-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 81601164; Medical Guidance Program of Science and Technology Innovation Plan in Shanghai, 18411961200; Municipal Human Resources Development Program for Outstanding Young Talents in Medical and Health Sciences in Shanghai, 2017YQ013; Feixiang Program of Shanghai Mental Health Center, 2016-FX-003; Multicenter Clinical Trial Project of Shanghai Jiao Tong University School of Medicine, DLY201818）。

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摘要： 物质成瘾是一种慢性、复发性脑病，涉及复杂的神经环路。目前，有关物质成瘾的治疗手段相对有限。重复经颅磁刺激（repetitive transcranial magnetic stimulation，rTMS）作为一种无创、安全性好、操作简单的神经电生理技术，已在精神疾病领域得到应用和推广。 rTMS治疗物质成瘾的效果与所调控的神经环路密切相关，但其机制尚不明确。该文总结了 rTMS技术在物质成瘾治疗中的应用以及 rTMS与其他治疗方法的联合应用情况，并介绍了 rTMS对物质成瘾相关神经环路的调控作用的研究进展。

关键词: 物质成瘾, 重复经颅磁刺激, 大脑神经环路, 治疗, 渴求

Abstract:

Substance addiction is a chronic and recurrent disorder and may be related to complex neural circuits. However, there is no optimally effective treatment for substance addiction currently. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive, safe and easy-to-operate neuroelectrophysiological technique, which is becoming an emerging therapeutic option for many mental disorders. The effect of rTMS on substance addiction is closely related to the stimulation of neural circuits. However, the mechanism is still unknown. The review summarizes recent research progress on the application of rTMS and its application combined with other therapies in substance addiction, as well as the regulation of rTMS on substance addiction-related neural circuits.

Key words: substance addiction, repetitive transcranial magnetic stimulation (rTMS), brain neural circuit, therapy, craving

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