上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2019, Vol. 39 ›› Issue (10): 1204-.doi: 10.3969/j.issn.1674-8115.2019.10.018

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髓源性抑制细胞的免疫调节作用及对肿瘤治疗的影响

李 潇，王 黎   

  1. 上海交通大学医学院附属瑞金医院血液科，医学基因组学国家重点实验室，上海血液学研究所，上海 200025
  • 出版日期:2019-10-28 发布日期:2019-11-22
  • 作者简介:李 潇（1994—），女，硕士生；电子信箱：2068641490@qq.com。
  • 基金资助:
    国家自然科学基金（81520108003，81670716，81830007）；上海市科学技术委员会课题 (16JC1405800)；上海市杰出青年医学人才培养资助计划；上海市教育委员会高峰高原学科建设计划（20152206）；上海市人才基金

Immunomodulatory effect of myeloid-derived suppressor cell and its impact on tumor therapy

LI Xiao, WANG Li   

  1. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2019-10-28 Published:2019-11-22
  • Supported by:
    National Natural Science Foundation of China, 81520108003, 81670716, 81830007; Project of Science and Technology Commission of Shanghai Municipality, 16JC1405800; Shanghai Outstanding Youth Medical Talents Training Funding Program; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Support, 20152206; Shanghai Talent Development Fund

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摘要： 髓源性抑制细胞（myeloid-derived suppressor cells，MDSCs）是一组具有强大免疫抑制功能的细胞。近年来，有关其在肿瘤发生和发展过程中的作用备受重视。许多临床研究发现，MDSCs在肿瘤患者的血液和瘤体内大量聚集，其水平的升高与肿瘤的不良预后密切相关，是一种有价值的肿瘤预测标志物；同时，MDSCs的免疫抑制功能亦可降低抗肿瘤的疗效。因此，探究MDSCs在肿瘤微环境中发挥免疫抑制作用的具体机制可为寻找新的免疫治疗方法提供参考。

关键词: 髓源性抑制细胞, 免疫抑制, 肿瘤治疗

Abstract:

Myeloid-derived suppressor cells (MDSCs) are a group of cells with potent immune suppressive activity which have emerged as an important contributor to tumor progression and genesis. More and more clinical researches have found that accumulation of MDSCs in peripheral blood and tumor tissues could predict dismal outcome for patients with malignancies, which was a potential prognostic tumor marker. In addition, immunosuppression inducedMDSCs could reduce the efficacy of anti-tumor therapies. Therefore, better understanding the mechanism of MDSCs’ immune suppression in tumor microenvironment can provide reference for exploring new immunotherapies.

Key words: myeloid-derived suppressor cell (MDSC), immunosuppression, tumor therapy

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