杏仁核介导的痛情绪神经环路研究进展

doi:10.3969/j.issn.1674-8115.2023.10.012

上海交通大学学报（医学版） ›› 2023, Vol. 43 ›› Issue (10): 1304-1310.doi: 10.3969/j.issn.1674-8115.2023.10.012

杏仁核介导的痛情绪神经环路研究进展

马翠(), 叶钰娟, 严兴科()

甘肃中医药大学针灸推拿学院，兰州 730000

收稿日期:2023-07-24 接受日期:2023-09-21 出版日期:2023-10-28 发布日期:2023-10-28
通讯作者: 严兴科，电子信箱：yanxingke@126.com。
作者简介:马翠（1994—），女，博士生；E-mail：mc754169434@126.com。
基金资助:
2023年度甘肃省省级重点人才项目([2023]20号);2021年甘肃省科技计划项目(21JR1RA266);国家自然科学基金(81460744);2023年甘肃省优秀博士生项目(23JRRA1222)

Research progress on the neural circuit of pain emotion mediated by amygdala

MA CUI(), YE Yujuan, YAN Xingke()

College of Acupuncture and Massage, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Received:2023-07-24 Accepted:2023-09-21 Online:2023-10-28 Published:2023-10-28
Contact: YAN Xingke, E-mail: yanxingke@126.com.
Supported by:
2023 Provincial Key Talent Project in Gansu Province ([2023]No.20);2021 Gansu Provincial Science and Technology Plan Project(21JR1RA266);National Natural Science Foundation of China(81460744);2023 Gansu Province Excellent Doctoral Program(23JRRA1222)

摘要/Abstract

摘要：

痛情绪的发生与特定中枢神经环路功能和结构改变密切相关。疼痛伴发抑郁、焦虑、痛厌恶记忆等情绪状态时，其激活或抑制的神经环路不同。边缘系统杏仁核（amygdala，AMY）参与疼痛与焦虑、抑郁、痛厌恶记忆等情绪的调节，并与疼痛和情绪相关的大脑核团存在广泛联系，共同调控疼痛、焦虑、抑郁、痛厌恶记忆等反应。该文对AMY介导的痛情绪相关的主要环路进行了梳理，总结出与抑郁相关的神经环路包括中央杏仁核→丘脑束旁核（CeA ^GABA→PF ^Glu）、中缝背核→中央杏仁核（DRN ^5-HT→CeA ^SOM）、中央杏仁核→腹外侧导水管周围灰质（CeA ^GABA→vlPAG ^GABA），与焦虑相关的神经环路包括腹侧被盖区→中央杏仁核（VTA→CeA^DA）、蓝斑→基底外侧杏仁核（LC ^NE→BLA），与痛厌恶记忆相关的神经环路为外侧臂旁核→中央杏仁核（lPBN ^CGRP→CeA ^CGRP）。其中，激活CeA ^GABA→PF ^Glu环路可导致抑郁伴疼痛，激活CeA ^GABA→vlPAG ^GABA环路可减轻抑郁导致的痛敏，激活DRN ^5-HT→CeA ^SOM环路可以缓解疼痛感受和抑郁情绪；激活VTA→CeA ^DA环路可以减轻痛敏以及焦虑样行为，抑制LC ^NE→BLA环路可缓解疼痛导致的焦虑；激活lPBN ^CGRP→CeA^CGRP环路可产生痛厌恶记忆。

关键词: 痛情绪, 杏仁核, 神经环路, 焦虑, 抑郁, 痛厌恶记忆

Abstract:

The occurrence of pain emotion is closely related to the functional and structural changes of specific central nervous circuit. When pain is accompanied by depression, anxiety, pain aversion memory and other emotional states, it activates or inhibits different neural circuits. The amygdala (AMY) of the limbic system participates in the regulation of pain, anxiety, depression, aversive memory and other emotions, and has extensive connections with brain nuclei related to pain and emotion, jointly regulating pain, anxiety, depression, aversive memory and other responses. This article summarizes the main circuits related to pain emotions mediated by AMY. It is concluded that the neural circuits related to depression include central amygdala → parafascicular nucleus of thalamus (CeA ^GABA → PF ^Glu), dorsal raphe nucleus → central amygdala (DRN ^5-HT → CeA ^SOM), central amygdala → ventrolateral periaqueductal gray (CeA ^GABA → vlPAG ^GABA). Nerve circuits related to anxiety include ventral tegmental area → central amygdala (VTA→CeA^DA), locus coeruleus → basolateral amygdala (LC^NE→BLA). The neural circuit related to pain aversion memory is lateral parabrachial nucleus → central amygdala (lPBN ^CGRP→CeA ^CGRP). Among them, activating the CeA^GABA→PF ^Glu circuit can lead to depression accompanied by pain, activating the CeA ^GABA→vlPAG ^GABA circuit can alleviate pain sensitivity caused by depression, and activating the DRN ^5-HT→CeA ^SOM circuit can alleviate pain perception and depressive emotions; activating the VTA→CeA ^DA loop can alleviate pain sensitivity and anxiety like behavior, inhibiting LC ^NE→BLA loop can alleviate anxiety caused by pain; activating the lPBN ^CGRP→CeA ^CGRP loop can generate pain aversion memory.

Key words: pain emotion, amygdala (AMY), nerve circuit, anxiety, depression, aversive memory

中图分类号:

R338.3

马翠, 叶钰娟, 严兴科. 杏仁核介导的痛情绪神经环路研究进展[J]. 上海交通大学学报（医学版）, 2023, 43(10): 1304-1310.

MA CUI, YE Yujuan, YAN Xingke. Research progress on the neural circuit of pain emotion mediated by amygdala[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(10): 1304-1310.

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杏仁核介导的痛情绪神经环路研究进展

Research progress on the neural circuit of pain emotion mediated by amygdala

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