肠道菌群在糖尿病认知功能障碍中的作用机制及靶向干预的研究进展

doi:10.3969/j.issn.1674-8115.2024.04.010

上海交通大学学报（医学版） ›› 2024, Vol. 44 ›› Issue (4): 494-500.doi: 10.3969/j.issn.1674-8115.2024.04.010

肠道菌群在糖尿病认知功能障碍中的作用机制及靶向干预的研究进展

杜亚格¹(), 卢言慧¹(), 安宇², 宋颖¹, 郑婕¹

^1.北京大学医学部护理学院，北京 100191
^2.首都医科大学附属北京朝阳医院内分泌科，北京 100020

收稿日期:2023-10-18 接受日期:2024-01-31 出版日期:2024-04-28 发布日期:2024-04-28
通讯作者: 卢言慧，电子信箱：luyanhui@bjmu.edu.cn。
作者简介:杜亚格（1995—），女，博士生；电子信箱：yuanfang166@163.com。
基金资助:
国家重点研发计划(2022YFA1103602);国家自然科学基金(82003456);北京大学临床医学+X青年专项(PKU2023LCXQ009);中央高校基本科研业务费资助

Research progress in mechanisms of gut microbiota in diabetic cognitive impairment and its targeted intervention

DU Yage¹(), LU Yanhui¹(), AN Yu², SONG Ying¹, ZHENG Jie¹

^1.School of Nursing, Peking University Health Science Center, Beijing 100191, China
^2.Endocrinology Department, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China

Received:2023-10-18 Accepted:2024-01-31 Online:2024-04-28 Published:2024-04-28
Contact: LU Yanhui, E-mail: luyanhui@bjmu.edu.cn.
Supported by:
National Key Research and Development Program of China(2022YFA1103602);National Natural Science Foundation of China(82003456);Peking University Clinical Medicine+X Youth Program(PKU2023LCXQ009);Fundamental Research Funds for the Central Universities

摘要/Abstract

摘要：

2型糖尿病进展后期可并发轻度认知功能障碍，并逐步发展为痴呆。糖尿病认知功能障碍（diabetic cognitive impairment，DCI）是糖尿病慢性并发症，相关发病机制仍有待阐明。研究发现肠道菌群失衡可通过“微生物-肠-脑轴”影响中枢神经系统，促进认知功能障碍的发生与发展，因此调控肠道菌群可能成为极具潜力的DCI的防治手段。基于此，该文梳理了肠道菌群在DCI中的作用机制，并总结了益生菌、粪菌移植、饮食与营养素、中医药等靶向肠道菌群的干预方法改善糖尿病相关的认知障碍、糖脂代谢和炎症的实验研究，从而为肠道菌群靶向干预DCI的临床应用提供参考。

关键词: 2型糖尿病, 认知功能障碍, 糖尿病认知功能障碍, 肠道菌群, 微生物-肠-脑轴

Abstract:

Diabetes mellitus type 2 might cause mild cognitive impairment in its advanced stages, potentially progressing to dementia. Diabetic cognitive impairment (DCI) stands as a chronic complication of diabetes mellitus, with its underlying pathogenesis still remaining elusive. Research has revealed that gut microbiota dysbiosis influenced the central nervous system through the "microbiota-gut-brain axis", thereby contributing to the progression of cognitive impairment. Therefore, the regulation of gut microbiota emerges as a promising approach to the prevention and treatment of DCI. This article comprehensively reviews the mechanisms through which gut microbiota influences DCI. Furthermore, it delves into experimental studies exploring targeted therapies for gut microbiota, including probiotics, fecal microbiota transplantation, dietary and nutrient interventions, as well as traditional Chinese medicine. These studies not only address diabetes-related cognitive impairment but also consider aspects such as glycolipid metabolism and inflammation. The insights gleaned from these studies provide valuable guidance for the clinical application of gut microbiota-targeted intervention in DCI.

Key words: diabetes mellitus type 2 (T2DM), cognitive impairment, diabetic cognitive impairment (DCI), gut microbiota, microbiota-gut-brain axis

中图分类号:

R259

杜亚格, 卢言慧, 安宇, 宋颖, 郑婕. 肠道菌群在糖尿病认知功能障碍中的作用机制及靶向干预的研究进展[J]. 上海交通大学学报（医学版）, 2024, 44(4): 494-500.

DU Yage, LU Yanhui, AN Yu, SONG Ying, ZHENG Jie. Research progress in mechanisms of gut microbiota in diabetic cognitive impairment and its targeted intervention[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(4): 494-500.

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肠道菌群在糖尿病认知功能障碍中的作用机制及靶向干预的研究进展

Research progress in mechanisms of gut microbiota in diabetic cognitive impairment and its targeted intervention

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