上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (6): 612-.

• 专题报道（抑郁障碍研究） • 上一篇    下一篇

色氨酸羟化酶2基因多态性与重症抑郁发作和治疗反应的关系分析

曹 岚, 方贻儒, 禹顺英, 胡莺燕, 洪 武, 张 晨, 易正辉, 苑成梅, 陈 俊, 吴志国, 李则挚, 黄 佳   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2010-06-25 发布日期:2010-06-28
  • 作者简介:曹 岚（1979—）, 女, 主治医师, 硕士|电子信箱: yirufang@yahoo.com.cn。
  • 基金资助:

    “十五”国家科技攻关计划(2004BA720A21-02)；国家高技术研究发展计划(“863”计划)（2006AA02Z430）；上海市“登山行动计划”（064119533）

Association of tryptophan hydroxylase 2 gene polymorphisms with major depression disorder and antidepressant treatment response

CAO Lan, FANG Yi-ru, YU Shun-ying, HU Ying-yan, Hong Wu, ZHANG Chen, YI Zheng-hui, YUAN Cheng-mei, CHEN Jun, WU Zhi-guo, LI Ze-zhi, HUANG Jia   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    National Key Technologies R&D Program of “10th Five-Year Plan”， 2004BA720A21-02；Hi-Tech Research and Development Program of China, “863” Program，2006AA02Z430；Shanghai “Climbing Mountain Action Plan” Program, 064119533

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摘要：

目的 分析中国汉族人群中色氨酸羟化酶2（TPH-2）基因单核苷酸多态性（SNP）rs4570625 和rs7305115位点与重症抑郁发作（MDD）和抗抑郁药物治疗反应的关系。方法 设立病例组（汉族MDD患者，n=346）和对照组（汉族正常人，n=347）；根据对治疗的反应，病例组患者再分为难治性抑郁症组（TRD组，n=72）和非TRD组（NTRD组，n=274）。通过Taqman探针SNP基因分型技术对TPH-2基因的 rs4570625和rs7305115位点进行基因分型，分析等位基因和基因型频率在各组间的分布差异。结果 病例组TPH-2基因rs4570625位点的基因型及等位基因分布的频率与对照组比较，差异有统计学意义（P<0.05）。按性别分层后，男性TRD组与男性NTRD组SNPs rs4570625和rs7305115位点的基因型和等位基因分布频率比较，差异有统计学意义（P<0.05）。结论 TPH-2基因rs4570625位点可能与抑郁症的发病有关；男性患者rs4570625和rs7305115位点的多态可能可用于预测对治疗的反应。

关键词: 重症抑郁发作, 治疗反应, 色氨酸羟化酶2, 基因

Abstract:

Objective To investigate the association of tryptophan hydroxylase 2 (TPH-2) gene single nucleotide polymorphisms (SNPs) of loci rs4570625 and rs7305115 with major depression disorder (MDD) and antidepressant treatment response in Chinese Han populations. Methods A total of 346 Chinese Han patients with MDD (case group) and 347 healthy Chinese Han people (control group) were enrolled, and patients in case group were subdivided into treatment-resistant depression (TRD) group (n=72) and non-TRD (NTRD) group (n=274) according to treatment response. SNPs of rs4570625 and rs7305115 were selected for the genomic region of TPH-2 gene and genotyped through TaqMan SNP genotyping assay, and the distribution of gene type and allele in groups was analysed. Results There were significant differences in distribution of rs4570625 gene type and allele between case group and control group (P<0.05). There were significant differences in distribution of SNPs rs4570625 and rs7305115 gene type and allele between males of TRD group and males of NTRD group (P<0.05). Conclusion TPH-2 gene rs4570625 may be associated with depression disorder in Chinese Han populations, and SNPs of rs4570625 and rs7305115 may predict the antidepressant treatment response in male patients.

Key words: major depression disorder, treatment response, tryptophan hydroxylase 2, gene