上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (2): 243-.doi: 10.3969/j.issn.1674-8115.2011.02.028

• 综述 • 上一篇    下一篇

Toll样受体4与脓毒症关系的研究进展

沈 婷1,2, 白建文1   

  1. 1.同济大学附属东方医院危重病科, 上海 200120；2.浙江省余姚市人民医院重症监护科, 余姚 315400
  • 出版日期:2011-02-28 发布日期:2011-03-01
  • 作者简介:沈 婷（1979—）, 女, 主治医师, 硕士生；电子信箱: shenting215200@sina.com。

Research progress of relationship between Toll like receptor 4 and sepsis

SHEN Ting1,2, BAI Jian-wen1   

  1. 1.Critical Care Division, Shanghai East Hospital,Tongji University, Shanghai 200120, China；2.Department of Intensive Care Unit, The People's Hospital of Yuyao, Yuyao 315400, China
  • Online:2011-02-28 Published:2011-03-01

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摘要：

Toll样受体（TLRs）是一类模式识别受体家族，它能通过介导细胞信号转导系统导致炎症因子的释放，从而在识别病原微生物、启动炎症应答中起重要作用。其中，TLR4是识别革兰阴性菌细胞外壁脂多糖成分的主要受体，因此在脓毒症的病理生理过程中，TLR4/CD14就成为了脂多糖诱导炎症反应最主要的通路。此外，TLR4的基因多态性与机体对脓毒症的个体易感性密切相关，这为疾病的诊断和治疗提供了重要的理论依据。

关键词: Toll样受体4, 脓毒症, 内毒素, 信号转导

Abstract:

Toll like receptors (TLRs) is a family of pattern recognizing receptors, which may lead to the release of inflammatory cytokines by inducing the cellular signal transduction system, and play an important role in recognizing pathogen and initiating inflammatory response. TLR4 is the major receptor recognizing gram-negative bacteria cell wall components including lipopolysaccharide, and the TLR4/CD14 signaling pathway is the most important way in inflammation reaction induced by lipopolysaccharide, which plays a key role in the pathogenesis of sepsis. The genetic polymorphism of TLR4 is associated with the individual susceptibility to sepsis, which provides important reference for the diagnosis and treatment of diseases.

Key words: Toll like receptor 4, sepsis, lipopolysaccharide, signal transduction