上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (3): 373-.doi: 10.3969/j.issn.1674-8115.2011.03.030

• 综述 • 上一篇    下一篇

肺癌分子诊断学研究进展

薛 剑, 娄加陶   

  1. 上海交通大学附属胸科医院检验科, 上海 200030
  • 出版日期:2011-03-28 发布日期:2011-03-29
  • 通讯作者: 娄加陶, 电子信箱: loujiatao@yahoo.com。
  • 作者简介:薛 剑(1981—), 男, 技师, 硕士；电子信箱: xue1269@hotmail.com。
  • 基金资助:

    上海市科委科技攻关项目(09441900702)

Research progress of molecular diagnostics of lung cancer

XUE Jian, LOU Jia-tao   

  1. Department of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2011-03-28 Published:2011-03-29
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 09441900702

PDF (PC)

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摘要：

肺癌的分子诊断作为影像学和细胞学筛查策略的重要补充，其内容不仅包括早期诊断，还包括预后指标及靶向治疗的预测等。该文拟对当前肺癌分子诊断的研究热点基因突变与靶向治疗预测、miRNA、肿瘤干细胞、甲基化及相关检测方法进行综述。

关键词: 基因突变, 靶向治疗, miRNA, 肿瘤干细胞, 甲基化

Abstract:

As a complement to imaging and cytology-based screening strategies, molecular diagnostics of lung cancer include not only the early detection but also the prognosis index and prediction of target therapy. In this paper, gene mutation, prediction of target therapy, miRNA, cancer stem cells and methylation in molecular diagnostics of lung cancer are reviewed.

Key words: gene mutation, target therapy, miRNA, cancer stem cell, methylation