自发性高血压大鼠丙泊酚麻醉后的认知功能研究

doi:10.3969/j.issn.1674-8115.2011.05.011

›› 2011, Vol. 31 ›› Issue (5): 576-.doi: 10.3969/j.issn.1674-8115.2011.05.011

自发性高血压大鼠丙泊酚麻醉后的认知功能研究

胡江, 李潺, 闻大翔, 杭燕南

上海交通大学医学院附属仁济医院麻醉科, 上海 200001

出版日期:2011-05-28 发布日期:2011-05-27
通讯作者: 闻大翔, 电子信箱: wdxrwj@gmail.com。
作者简介:胡江（1985—）, 女, 硕士生；电子信箱: hujiang84@hotmail.com。
基金资助:
上海市科委基金（09JC1409500）

Cognitive function after anesthesia with propofol in spontaneously hypertensive rats

HU Jiang, LI Chan, WEN Da-xiang, HANG Yan-nan

Department of Anesthesiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China

Online:2011-05-28 Published:2011-05-27
Supported by:
Shanghai Science and Technology Committee Foundation, 09JC1409500

摘要/Abstract

摘要：

目的评估自发性高血压大鼠（SHR）丙泊酚麻醉后的认知功能。方法将24只3月龄雄性SHR随机分为对照组和丙泊酚组，分别腹腔注射等体积的生理盐水和丙泊酚。采用无创尾动脉血压测定分析系统测量给药前、给药后即刻和给药后3 h大鼠的平均动脉压（MAP）和脉搏变化情况。采用经典Morris水迷宫，给药后1 d 开始行定位航行实验，连续7 d，比较两组的逃避潜伏期；第7天去除平台行空间探索实验，比较两组停留在原平台象限的时间百分比。结果丙泊酚组给药后即刻和给药后3 h的MAP和脉搏较基础值和对照组均显著下降，差异有统计学意义（P<0.05）。随着学习时间的延长，两组逃避潜伏期均逐渐缩短，其中训练第2~4天，对照组的逃避潜伏期明显短于丙泊酚组，差异有统计学意义（P<0.05）；第5~7天，两组成绩逐渐接近，差异无统计学意义（P>0.05）。空间探索实验显示，两组大鼠在原平台象限的停留时间百分比超过25％，均高于其他象限。结论经丙泊酚麻醉的SHR会出现一过性的血压和脉搏下降，并在短期内产生认知功能障碍，主要表现在训练初期；给予足够训练后的SHR认知功能可恢复到正常水平。

关键词: 自发性高血压大鼠, 丙泊酚, Morris水迷宫, 认知功能

Abstract:

Objective To evaluate the cognitive function after anesthesia with propofol in spontaneously hypertensive rats (SHR). Methods Twenty-four male SHR of three months old were randomly divided into control group and propofol group, and were peritoneally injected with same volumes of normal saline and propofol, respectively. The changes of mean arterial pressure (MAP) and pulse were detected before administration, immediately after administration and 3 h after administration by non-invasive blood pressure monitoring system. Rats were subjected to Morris water maze tests. Place navigation trails started 1 d after administration and lasted for 7 d, and escape latencies of two groups were compared. Spatial probe trials were conducted on the seventh day after platform removal, and the time percents during stay in each quadrant of two groups were compared. Results MAP and pulse detected immediately after administration and 3 h after administration in propofol group were significantly lower than the baseline data and those in control group (P<0.05). The escape latencies of both groups decreased with time of training, the escape latency of control group was significantly shorter than that of propofol group 2 to 4 d after training (P<0.05), and there was no significant difference in the escape latency between two groups 5 to 7 d after training (P>0.05). Spatial probe trials revealed that the time percents during stay in the platform quadrant in two groups were more than 25%, and both were higher than those during stay in the other quadrants. Conclusion SHR may experience transient hypotension and bradycardia after anesthesia with propofol, and there may be cognitive function impairment in a short time. The cognitive function can be recovered to normal levels after enough training.

Key words: spontaneously hypertensive rat, propofol, Morris water maze, cognitive function

胡江, 李潺, 闻大翔, 等. 自发性高血压大鼠丙泊酚麻醉后的认知功能研究[J]. , 2011, 31(5): 576-.

HU Jiang, LI Chan, WEN Da-xiang, et al. Cognitive function after anesthesia with propofol in spontaneously hypertensive rats[J]. , 2011, 31(5): 576-.

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自发性高血压大鼠丙泊酚麻醉后的认知功能研究

Cognitive function after anesthesia with propofol in spontaneously hypertensive rats

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