上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (5): 625-.doi: 10.3969/j.issn.1674-8115.2011.05.021

• 论著（临床研究） • 上一篇    下一篇

糖尿病肾病与载脂蛋白E基因多态性相关性的Meta分析

王 袁, 吴琪俊, 施 榕   

  1. 上海交通大学 公共卫生学院, 上海 200025
  • 出版日期:2011-05-28 发布日期:2011-05-27
  • 通讯作者: 施 榕, 电子信箱: shirong61@yahoo.com.cn。
  • 作者简介:王 袁（1986—）, 男, 硕士生；电子信箱: wangyuan0828@126.com。

Meta-analysis of association of ApoE gene polymorphisms with |diabetic nephropathy

WANG Yuan, WU Qi-jun, SHI Rong   

  1. School of Public Health, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2011-05-28 Published:2011-05-27

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摘要：

目的 评价载脂蛋白E (ApoE)基因多态性与2型糖尿病（T2DM）患者发生糖尿病肾病（DN）的相关性，为DN的早期基因诊断提供循证医学的证据。方法 查阅有关我国T2DM人群与ApoE基因多态性研究的相关文献，利用Meta分析系统性评价T2DM患者中并发DN（DN组）与未并发DN（对照组）患者的ApoE基因型分布和等位基因频率进行分析和比较，计算比值比（OR值）。结果 实际纳入文献14篇，总计2 730例T2DM患者，其中DN组1 528例，对照组1 202例。Meta分析结果显示：与E3/3基因型相比，E2/3（OR=1.776，P=0.000）和E3/4（OR=1.417，P=0.003）基因型患者更容易发生DN；与等位基因ε3相比，等位基因ε2（OR=1.678，P=0.000）和ε4（OR=1.219，P=0.048）携带患者更容易发生DN。结论 ApoE基因多态性与T2DM患者DN的发生相关。基因型E2/3、E3/4和等位基因ε2、ε4可能是我国T2DM患者并发DN的危险因子。

关键词: 载脂蛋白E, 糖尿病肾病, 2型糖尿病, Meta分析

Abstract:

Objective To evaluate the association of apolipoprotein E (ApoE) gene polymorphisms with diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM), and provide evidence of gene diagnosis of DN. Methods All related literatures on association of Chinese patients with T2DM and ApoE gene polymorphisms were retrieved. ApoE genotype distribution and allele frequency of DN in patients with T2DM (DN group) and non-DN in patients with T2DM  (control group) were analysed and compared through Meta-analysis, and odds ratios (OR) were calculated, respectively. Results A total of 14 literatures were retrieved, and 2 730 patients with T2DM were included, with 1 528 in DN group and 1 202 in control group. Meta analysis revealed that compared with genotype E3/3, genotype E2/3 (OR=1.776，P=0.000) and genotype E3/4 (OR=1.417，P=0.003) were more susceptible to DN, and compared with allele ε3, allele ε2 （OR=1.678，P=0.000）and allele ε4 （OR=1.219，P=0.048） were more susceptible to DN. Conclusion ApoE gene polymorphisms may be associated with DN in patients with T2DM, and genotype E2/3, genotype E3/4, allele ε2 and allele ε4 may be risk factors of DN in Chinese patients with T2DM.

Key words: ApoE, diabetic nephropathy, type 2 diabetes mellitus, Meta analysis