上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (6): 848-.doi: 10.3969/j.issn.1674-8115.2011.06.038

• 综述 • 上一篇    下一篇

放疗联合溶瘤病毒治疗对肿瘤细胞的影响

姚玉亭1,2, 钱关祥2, 葛盛芳1,2   

  1. 上海交通大学 1.医学院附属第九人民医院眼科, 上海 200011； 2.基础医学院生物化学与分子生物学教研室, 上海 200025
  • 出版日期:2011-06-28 发布日期:2011-06-27
  • 通讯作者: 葛盛芳, 电子信箱: geshengfang@sjtu.edu.cn。
  • 作者简介:姚玉亭（1987—）, 女, 硕士生；电子信箱: ytyao89@yahoo.cn。
  • 基金资助:

    国家自然科学基金（10979034）和上海市重点学科基金（S30205）

Impact of oncolytic viruses in combination with radiotherapy on tumor cells

YAO Yu-ting1,2, QIAN Guan-xiang2, GE Sheng-fang1,2   

  1. 1.Department of Ophthalmology, the Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China；2.Department of Biochemistry and Molecular Biology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2011-06-28 Published:2011-06-27
  • Supported by:

    National Natural Science Foundation of China, 10979034；Shanghai Key Discipline Foundation, S30205

PDF (PC)

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摘要：

溶瘤病毒治疗是近年来兴起的一种新的肿瘤基因治疗途径。在溶瘤腺病毒被批准用于临床治疗肿瘤的情况下，溶瘤病毒治疗与放疗相结合将对恶性肿瘤的治疗产生重要影响。文章就放疗联合溶瘤病毒治疗对肿瘤细胞的杀伤作用作一综述。

关键词: 溶瘤病毒, 放疗, 肿瘤, 基因治疗

Abstract:

Oncolytic viruses have been developed as a new approach for the treatment of cancer. Oncolytic viruses in combination with radiotherapy may have an important impact for the treatment of metastatic cancer after the approval of oncolytic adenovirus for clinical tumor treatment. In this review, the killing effects on tumor cells of oncolytic viruses in combination with radiotherapy are discussed.

Key words: oncolytic virus, radiotherapy, tumor, gene therapy