上海交通大学学报（医学版）

›› 2011, Vol. 31 ›› Issue (11): 1588-.doi: 10.3969/j.issn.1674-8115.2011.11.018

• 论著（临床研究） • 上一篇    下一篇

DNA修复基因XRCC1 codon 399多态性与肝细胞癌易感性的meta分析

陈秉朴1, 龙喜带2, 傅国辉2   

  1. 1.右江民族医学院解剖学教研室, 百色 533000； 2.上海交通大学 基础医学院病理学教研室, 上海 200025
  • 出版日期:2011-11-28 发布日期:2011-11-29
  • 作者简介:陈秉朴(1968—), 男, 副教授, 硕士生, 壮族；电子信箱: gxcbp@sina.com。
  • 基金资助:

    广西青年科学基金（0832097）；国家自然科学基金（81160255）

Meta-analysis of XRCC1 Codon 399 polymorphism and susceptibility to hepatocellular carcinoma

CHEN Bing-pu1, LONG Xi-Dai2, FU Guo-hui2   

  1. 1.Department of Anatomy, Youjiang Medical College for Nationalities, Baise 533000, China；2.Department of Pathology, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2011-11-28 Published:2011-11-29
  • Supported by:

    Youth Science Foundation of Guangxi, 0832097；National Natural Science Foundation of China, 81160255

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摘要：

目的 探讨DNA修复基因X线修复交叉互补因子1（XRCC1）codon 399多态性与肝细胞癌(HCC)易感性的关系。方法 检索文献并按要求提取相关信息，纳入以XRCC1 codon 399多态性与HCC易感性为内容的病例—对照研究，对研究结果进行meta分析。通过异质性检验选择固定效应模型或随机效应模型计算合并的优势比（OR）及其95%可信区间（95%CI），并进行发表偏倚评估和敏感性分析。结果 本研究共纳入国内外合格文献7篇（HCC患者1 342例，对照2 207例）。合并分析结果显示：XRCC1 codon 399 Gln/Gln基因型可使HCC的发病风险增加（OR=1.41, 95% CI 1.07~1.84），而Lys/Gln基因型与HCC的发病风险无明显关联。进一步的亚组分析结果显示：在HCC高发区人群中，Lys/Gln和Gln/Gln基因型均与HCC发病存在关联性（OR=1.46, 95% CI 1.07~2.00; OR=1.45, 95% CI 1.09~1.93）。结论 XRCC1基因codon 399多态性与HCC的易感性相关。

关键词: 肝细胞癌, X线修复交叉互补因子1, meta分析, 基因多态性

Abstract:

Objective To explore the relationship between X-ray repair cross-complementary group 1(XRCC1) codon 399 polymorphism and genetic susceptibility to hepatocellular carcinoma (HCC). Methods Literatures of case-control studies about XRCC1 codon 399 polymorphism and genetic susceptibility to HCC were retrieved, related information was extracted, and meta-analysis was performed on research findings. Odds ratios (ORs) and 95% confidence interval (95% CI) were calculated using fixed- or random-effects model via heterogeneity test, and the publication bias and sensitivity were evaluated. Results Seven domestic and overseas literatures were enrolled, including 1 342 cases of HCC and 2 207 controls. The combined data analysis indicated that XRCC1 codon 399 Gln/Gln increased risk for HCC (OR=1.41, 95% CI=1.07-1.84), while XRCC1 codon 399 Lys/Gln was not related to risk for HCC. Subgroup analysis revealed that both Lys/Gln and Gln/Gln were related to HCC in areas with high incidence of HCC （OR=1.46, 95% CI 1.07-2.00; OR=1.45, 95% CI 1.09-1.93）. Conclusion XRCC1 codon 399 polymorphism is associated with the susceptibility to HCC.

Key words: hepatocellular carcinoma, X-ray repair cross-complementary group 1, meta-analysis, genic polymorphism