上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (2): 245-.doi: 10.3969/j.issn.1674-8115.2013.02.024

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胰岛β细胞放射性核素分子显像研究进展

刘 帅, 张一帆   

  1. 上海交通大学 医学院附属瑞金医院核医学科, 上海 200025
  • 出版日期:2013-02-28 发布日期:2013-03-07
  • 通讯作者: 张一帆, 电子信箱: yifanzhang1992@yahoo.com.cn。
  • 作者简介:刘 帅（1987—）, 女, 硕士； 电子信箱: elaine_liu87@yahoo.com.cn。

Research progress of radionuclide molecular imaging in pancreatic beta cells

LIU Shuai, ZHANG Yi-fan   

  1. Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-02-28 Published:2013-03-07

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摘要：

糖尿病是严重威胁人类健康的常见病和多发病，胰岛素替代治疗是其主要的治疗手段。近年来，胰岛β细胞移植治疗1型糖尿病展示出潜在的应用前景，但如何在活体条件下无创地进行胰岛β细胞移植的监测，是目前临床应用所面临的重要问题。放射性核素分子显像技术近年来得到了快速发展，具有灵敏度高、特异性强等特点，在胰岛β细胞移植监测方面得到了广泛应用，展示了良好的应用前景。

关键词: 糖尿病, 胰岛β细胞移植, 分子显像

Abstract:

Diabetes is a common disease that poses great threat to human health. At present, insulin replacement therapy remains the main treatment. In recent years, pancreatic beta cell transplantation has demonstrated potential prospect in treatment of type 1 diabetes, however, it is an important issue in clinical application on the non-invasive monitoring of in vivo pancreatic beta cell transplantation. Radionuclide molecular imaging technology, which has been developing rapidly with high sensitivity and specificity, has been widely applied in monitoring pancreatic beta cell transplantation, and has demonstrated favorable prospect in application.

Key words: diabetes, pancreatic beta cell transplantation, molecular imaging