›› 2012, Vol. 32 ›› Issue (11): 1512-.doi: 10.3969/j.issn.1674-8115.2012.11.024

• Review • Previous Articles     Next Articles

Application of radionuclide reporter gene imaging in therapeutic gene monitoring

PAN Yu, ZHANG Yi-fan   

  1. Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2012-11-28 Published:2012-11-30
  • Supported by:

    National Natural Science Foundation of China, 81171367;Innovation Program of Shanghai Education Committee, 12YZ041


As a new disease therapy method, gene therapy shows a broad application prospect. However, there are still lots of problems in gene therapy to be solved. To evaluate the efficiency of gene therapy, it is requisite to monitor and evaluate the localization and expression of the therapeutic gene in vivo. Radionuclide reporter gene imaging, with rapid development in recent years, is considered as a non-invasive and sensitive method in monitoring the expression of the therapeutic gene in vivo. This method, which has the advantage of high sensitivity and specificity and may carry on deep-tissue imaging and repeat imaging, has shown a good application prospect. The mechanism, characteristics and value of radionuclide reporter gene imaging in monitoring gene therapy are reviewed in this paper.

Key words: reporter gene, radionuclide imaging, gene therapy, molecular imaging