›› 2015, Vol. 35 ›› Issue (10): 1550-.doi: 10.3969/j.issn.1674-8115.2015.10.024

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Advances of metabolic syndrome in patients with bipolar disorders

XIANG Hui, WANG Zuo-wei, FANG Yi-ru   

  1. Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Natural Science Foundation of China, 91232719; National Key Technology Research and Development Program of the Ministry of Science and Technology of China in the “12th Five-year Plan”, 2012BAI01B04; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873


Metabolic syndrome (MS) has been identified as a series of insulin resistance-caused clinical, biochemical, and humoral metabolic abnormalities, which result in metabolic abnormalities of many matters. The correlation between MS and bipolar disorder (BD) is still unclear. The side effects of psychotropic medications may be major contributors to the increased incidence of MS of patients with BD. Other factors such as unhealthy lifestyle, neuroendocrine and immunoinflammatory abnormalities, and genetic vulnerability may also play a role. Many studies show that the risk of incidence of MS of patients with BD is significantly higher than that of general population and is a major reason for poor prognosis of BD, which indicate that prevention of MS for the treatment of BD is important. This paper reviews research advances of epidemiology, pathophysiological mechanisms, prevention, and treatment of MS for patients with BD.

Key words: metabolic syndrome, bipolar disorder, obesity, diabetes mellitus