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Research progresses in pathogenesis, diagnosis, and treatment of diabetic gastroparesis

FENG Ri-lu, MA Jing   

  1. Department of Endocrinology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    Shanghai Municipal Health Bureau, 20124273; Science and Technology Commission of Shanghai Municipality,14441903502; Shanghai Jiao Tong University School of Medicine, Science and Technology Fund,12XJ10015


Diabetic gastroparesis (DGP) is characterized by delayed gastric emptying in patients with prolonged type 1 and type 2 diabetes mellitus. Common symptoms include nausea, vomiting, bloating, and epigastric pain. Gastroparesis results in malnutrition, impaired drug absorption, and disordered glycaemic control and affects the quality of life. The clinical management of diabetic gastroparesis is not ideal due to unclear pathogenesis and the ignorance of changes in gastric motility. It has been recognized that autonomic neuropathy and hyperglyaemia are main contributors to the gastrointestinal dysfunction in diabetic patients. Therefore, current treatments mainly relieve gastrointestinal symptoms and control the blood sugar. Combining with progresses of intestinal motility research in recent years, this paper reviews the pathogenesis, diagnosis, and treatment of diabetic gastroparesis.

Key words:  gastroparesis, hyperglycaemia, glucagon-like peptide-1, diabetes mellitus