›› 2011, Vol. 31 ›› Issue (4): 443-.doi: 10.3969/j.issn.1674-8115.2011.04.013

• Original article (Clinical research) • Previous Articles     Next Articles

Experimental study of feasibility of miniature implantable spinal cord stimulation system

GUAN Hong-xin1, ZHONG Jun1, WANG Hui2, ZHU Jin1, YANG Min1, YANG Xiao-sheng1, ZHOU Qiu-meng1, JIAO Wei1   

  1. 1.Department of |Neurosurgery, Xinhua Hospital|Shanghai Jiaotong University School of Medicine, Shanghai 200092, China；2.Micro-Nano Device Research Center, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201203, China
  • Online:2011-04-28 Published:2011-04-28
  • Supported by:

    Shanghai Education Committee Foundation, 10YZ42；Foundation from Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 08YZ08

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Abstract:

Objective To investigate the feasibility of self-made miniature implantable spinal cord stimulation system in animal experiment. Methods Twenty healthy adult SD rats were selected. The spinal cord stimulation electrode was placed on the dorsal epidural C2 cervical spinal cord, and the battery and stimulation device were implanted under the skin. Neurological behavior scoring (BBB score) and inclined plane test were conducted before operation(0 h) and 12 h, 24 h and 36 h after operation, and the body weight was measured. The stimulation parameters (voltage, pulse width and frequency) were determined 12 h, 24 h and 36 h after operation. Results There was no significant difference in the stimulation parameters among the time points of 0 h, 12 h and 24 h (P>0.05), while there were significant differences between the time points of 0 h and 36 h (P<0.05). There were significant differences in the results of BBB score, inclined plane test and body weight measurement between the time points of 0 h and 12 h (P<0.05), while there was no significant difference between the time points of 0 h and 24 h and 36 h (P>0.05). There was no significant adverse effect in rats during the experiment. Conclusion The self-made miniature implantable spinal cord stimulation system is safe, and is suitable for animal experiments.

Key words: spinal cord stimulation, experimental study, rat