Abstract:

Objective  To comprehensively assess the therapeutic effect of 5 antipsychotic drugs, i.e. aripiprazole (Ari), olanzapine (Ole), paliperidone (Pla), quetiapine (Que), and risperidone (Ris), on patients with schizophrenia by using the network meta-analysis. Methods  Papers were retrieved from PubMed, Cochorane Library, CNKI, China Science and Technology Journal Database, China Science Periodical Database, and Chinese Science Citation Database according to the predefined inclusion and exclusion criteria and quality assessment was conducted. The Bayesian network model was established by WinBUGS1.4.3 and the priority of recommendation levels was estimated by the OR value of drugs. Results  A total of 5280 patients were enrolled in 60 clinical tests. The results of network meta-analysis showed that compared with Pal, Ari, Ola and Ris, Que significantly improved the clinical efficiency. OR (Pal, Que)=0.415 4 (95%CI: 0.252 9-0.636 7), OR (Pal, Ris)=0.674 4 (95%CI: 0.521 7-0.855 5), OR (Ari, Que)=0.5491 (95%CI: 0.298 8-0.909 6), OR (Ola, Que)=0.474 6 (95%CI: 0.280 5-0.755 8), and OR (Que, Ris)=1.694 (95%CI: 1.115-2.495). The differences were statistically significant. Conclusion  Based on the results of network meta-analysis, the recommendation level of Que is higher than that of other drugs. But further evidences are needed to verify the therapeutic effect due to lack of studies.

Key words: schizophrenia, bayesian model, network meta-analysis