›› 2017, Vol. 37 ›› Issue (12): 1581-.doi: 10.3969/j.issn.1674-8115.2017.12.001

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Relationship between neuropeptide Y gene polymorphism and schizophrenia

ZHAO Jing1, Lü Qin-yu1, LU Ying1, HU Guo-qin1, BAO Chen-xi1, ZHU Ming-huan1, JIA Si1, CHENG Xiao-yan1, GENG Rui-jie1, JIANG Ya-qin2, YU Shun-ying1#, YI Zheng-hui1#     

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Hongkou District Mental Health Center,
    Shanghai 200083, China
  • Online:2017-12-28 Published:2018-01-10
  • Supported by:
    National Basic Research Program of China “Precision Psychiatry Program”, 2016YFC0906402; National Key R & D Program of China, 2016YFC1305904; National Natural Science Foundation of China, 81171272, 81671326; Shanghai Science and Technology Commission Foundation, 17411970000; The Fundamental Research Funds for the Central Universities of Shanghai Jiao Tong University, 16JXRZ06

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Abstract: [Abstract] Objective · To explore the association between neuropeptide Y (NPY) gene polymorphism and schizophrenia in Chinese Han population.
Methods · Four single nucleotide polymorphism (SNP) loci (rs16148, rs1859290, rs16147, and rs16478 in NPY gene) were selected and genotyped
by TaqMan genotyping assay in a case-control study with 678 schizophrenia cases (case group) and 685 healthy controls (control group). The allele,
genotype and haplotype frequencies distribution of the SNPs between the groups were compared with SHEsis online software. Results · The distribution
of genotype frequency of locus rs16478 showed a nominal statistically difference between the adult-onset schizophrenia (AOS group) and control
group (χ2=6.66, P=0.036, P correction=0.144). Under recessive inherited model, the distribution of CC genotype frequency of locus rs1859290 showed
statistically difference between the male schizophrenia cases and control group (P=0.012, OR=0.97, 95%CI 0.94-0.99, P correction=0.048). The
distribution of haplotype CCTA (consisted of rs16148, rs1859290, rs16147, and rs16478) frequency showed statistically difference between the male AOS
group and control group (8.1% vs 13.2%, OR=0.57, P=0.010, P correction=0.040). Conclusion · The polymorphisms in NPY gene may be associated with
schizophrenia in Chinese Han population.

Key words: neuropeptide Y, schizophrenia, association study, single nucleotide polymorphism