A comparative study of prepulse inhibition in children with first episode schizophrenia and normal children

doi:10.3969/j.issn.1674-8115.2023.05.011

Abstract

Abstract:

Objective ·To explore the characteristics of sensory gating and its variation in children with first episode schizophrenia (COS) by using a new technique of prepulse suppression (PI). Methods ·By using the ERP recording and analysis system of brain products, PI was detected in 56 patients with COS and 38 healthy children (NC) using the paradigm of single strong stimulus and weak stimulus+strong stimulus. The patients′ performance was comprehensively evaluated with Positive and Negative Syndrome Scale (PANSS), Social Disability Screening Schedule (SDSS), Social Adjustment Rating Scale (SSRS), and Family Interview Schedule (FIS). Results ·The social objective support formed by summing up the above scales was compared with the quantitative stanard of social support [the standard of social support scale was (8±2) points, and the value of COS group was (10±3) points], and the difference was statistically significant (P=0.007). No correlation was found between PI and PANSS total score and each factor score (all P>0.05). The latency of startle reflex in the COS group was longer than that in the NC group [the NC group was (86±11) ms, the COS group was (97±13) ms, P=0.001]. In the COS group, the amplitude of startle reflex of weak stimulus+strong stimulus was higher, and the latency was longer than that of the NC group [NC group: (39±12) μV, COS group (47±21) μV, P=0.007; the latency of the normal group was (84±17) ms, and that of the COS group was (97±20) ms, P=0.003]. PI inhibition rate in the COS group was lower than that in the NC group [(66±32) % in the NC group, (43±37) % in the COS group, P=0.000]. Conclusion ·COS patients have the same PI abnormality as adult schizophrenia. The change of PI inhibition may be the result of biological markers reflecting the change of agitated emotion in COS patients.

Key words: schizophrenia, children, prepulse inhibition (PI), biological markers (BM)

CLC Number:

R749.94

XU Xiaojun, YE Minjie, WANG Yuchen, WANG Wenxia, QIAN Sheng, YE Dandi, PAN Lele, HU Xin, YIN Xiaoli, LI Meihua, LING Guangyao. A comparative study of prepulse inhibition in children with first episode schizophrenia and normal children[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(5): 606-610.

Figures/Tables 3

TrendMD

References 16

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Project	COS group	NC group	t/χ²	P value
Project	(n=56)	(n=38)	t/χ²	P value
Age	14.3±1.3	13.4±1.5	1.495	0.122
Gender (male/female)/[n (%)]	29 (51.2)/27 (48.8)	20 (52.6)/18 (47.4)	0.656	0.412
Nation	Han nationality	Han nationality	N/A	N/A
Hearing	Normal	Normal	N/A	N/A
Family history of mental disorder	No	No	N/A	N/A
Year of education/year	6.5±1.2	6.4±1.3	0.591	0.551
Course of disease/month	3.80±2.7	N/A	N/A	N/A
PANSS total/score	98±10.5	N/A	N/A	N/A
Positive symptom/score	25.2±4.2	N/A	N/A	N/A
Negative symptom/score General sychopathology/score	23.9±7.9	N/A	N/A	N/A
Negative symptom/score General sychopathology/score	36.7±5.4	N/A	N/A	N/A

Project	COS group	NC group	t/χ²	P value
Project	(n=56)	(n=38)	t/χ²	P value
Age	14.3±1.3	13.4±1.5	1.495	0.122
Gender (male/female)/[n (%)]	29 (51.2)/27 (48.8)	20 (52.6)/18 (47.4)	0.656	0.412
Nation	Han nationality	Han nationality	N/A	N/A
Hearing	Normal	Normal	N/A	N/A
Family history of mental disorder	No	No	N/A	N/A
Year of education/year	6.5±1.2	6.4±1.3	0.591	0.551
Course of disease/month	3.80±2.7	N/A	N/A	N/A
PANSS total/score	98±10.5	N/A	N/A	N/A
Positive symptom/score	25.2±4.2	N/A	N/A	N/A
Negative symptom/score General sychopathology/score	23.9±7.9	N/A	N/A	N/A
Negative symptom/score General sychopathology/score	36.7±5.4	N/A	N/A	N/A

Index	PI	R
PANSS scale point total	0.11	0.42
Positive scale point	0.07	0.54
Negative scale point	0.12	0.33
General psychosis scale point	0.12	0.44
Lack response factor	0.11	0.42
Thinking disorder factor	0.03	0.76
Activeness factor	0.27	0.04
Paranoia factor	0.16	0.17
Depressed factor	0.06	0.56

Index	PI	R
PANSS scale point total	0.11	0.42
Positive scale point	0.07	0.54
Negative scale point	0.12	0.33
General psychosis scale point	0.12	0.44
Lack response factor	0.11	0.42
Thinking disorder factor	0.03	0.76
Activeness factor	0.27	0.04
Paranoia factor	0.16	0.17
Depressed factor	0.06	0.56

Group	n	Single strong stimulation		Weak stimulation+strong stimulation		PI%
Group	n	Latency/ms	Amplitude/μV	Latency/ms	Amplitude/μV	PI%
Cz Brain region
NC group	38	86±11	72±39	84±17	39±12	66±32
COS group	56	97±13^①	74±41	97±20^②	47±21^③	43±37^④
Fz Brain region
NC group	38	87±9	71±38	83±17	38±12	65±31
COS group	56	96±13^⑤	72±40	96±20^⑥	39±20	43±36^①
Pz Brain region
NC group	38	86±10	70±37	83±16	37±11	66±32
COS group	56	85±12	88±40^③	89±19	46±20^⑦	44±31^④