Research progress of arginine metabolism in the regulation of mesenchymal stem cell function

doi:10.3969/j.issn.1674-8115.2025.07.013

Abstract

Abstract:

Mesenchymal stem cells (MSCs) are adult stem cells that exist in bone marrow, fat, cord blood, bone, muscle and other tissues. MSCs not only have the unique self-renewal ability and multidirectional differentiation potential of stem cells, but also have the function of immune regulation. Arginine is a conditionally essential amino acid, and its metabolic regulation is essential for maintaining cell function and overall health. In MSCs, arginine metabolism may have a certain effect on cell proliferation, differentiation, inflammatory response, and tumor development. This article summarizes the effects of arginine metabolism on the differentiation, inflammation, immunity, and tumor development in different types of MSCs, discusses new strategies for the treatment of metabolic syndrome, and provides new ideas for the treatment of inflammatory diseases and tumors by MSCs from the perspective of arginine metabolism.

Key words: mesenchymal stem cells, arginine metabolism, cell differentiation, inflammation

CLC Number:

KERANMU Saitierguli, QIAN Lei, DING Siyi, MAHELIMUHAN Hanati, YANG Xueer, JIA Hao. Research progress of arginine metabolism in the regulation of mesenchymal stem cell function[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(7): 910-915.

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References 41

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