›› 2011, Vol. 31 ›› Issue (9): 1328-.doi: 10.3969/j.issn.1674-8115.2011.09.027

• Review • Previous Articles     Next Articles

Clinical application of heart ischemic preconditioning and postconditioning

XU Yuan-lin, WANG Wei   

  1. Department of Cardiovascular and Thoracic Surgery, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Online:2011-09-28 Published:2011-09-27


Heart ischemic preconditioning and postconditioning may have a protective effect against ischemia-reperfusion injury. Heart ischemic preconditioning can improve myocardial tolerance to ischemia, reduce myocardial infarct size, protect endothelial function, and is associated with significant reduction in ventricular arrhythmias, inotrope requirement and intensive care unit stay. Ischemic postconditioning may attenuate cardiomyocyte apoptosis and improve the recovery of left ventricular systolic function. This article focuses on the clinical application, main mechanism and influencing factors of heart ischemic preconditioning and postconditioning.

Key words: heart, ischemic preconditioning, ischemic postconditioning