›› 2013, Vol. 33 ›› Issue (2): 231-.doi: 10.3969/j.issn.1674-8115.2013.02.021

• Review • Previous Articles     Next Articles

Impact of atypical antipsychotics on adiponectin

YANG Lin1,2, CHEN Jian-hua2, XU Yi-feng2   

  1. 1.Department of Psychiatry, Huashan Hospital, Fudan University, Shanghai 200021, China; 2.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    National Natural Science Foundation of China, 81171271; Shanghai Science and Technology Committee Foundation, 11ZR1431300; National Key Clinical Disciplines at Shanghai Mental Health Center, Office of Medical Affairs, the Ministry of Health of China, 2011-873


Metabolic syndrome (MS) may be caused by atypical antipsychotics (AAPs), and the possible mechanisms have not been fully revealed. Adipocytes regulate energy metabolism through release of adipocytokines. Studies have demonstrated that the impact of AAPs on adipokines is one of the potential mechanisms of drug-induced MS, and adiponectin is an important adipocytokine closely related to MS. The association between AAPs-induced MS and adiponectin is reviewed in this paper.

Key words: antipsychotics, metabolic syndrome, adipocytokines, adiponectin