上海交通大学学报(医学版) ›› 2022, Vol. 42 ›› Issue (3): 387-392.doi: 10.3969/j.issn.1674-8115.2022.03.019

• 综述 • 上一篇    下一篇

线粒体自噬异常在阿尔茨海默病中的作用及机制研究综述

林祎嘉(), 程丽珍, 苗雅()   

  1. 上海交通大学医学院附属第六人民医院老年病科,上海 200233
  • 收稿日期:2021-10-28 出版日期:2022-03-28 发布日期:2022-03-16
  • 通讯作者: 苗雅 E-mail:linyijia2020@126.com;nning-my@163.com
  • 作者简介:林祎嘉(1998—),女,硕士生;电子信箱:linyijia2020@126.com
  • 基金资助:
    上海市自然科学基金(19ZR1438800)

Research progress in the role and mechanism of abnormal mitophagy in Alzheimer's disease

Yijia LIN(), Lizhen CHENG, Ya MIAO()   

  1. Department of Geriatrics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China
  • Received:2021-10-28 Online:2022-03-28 Published:2022-03-16
  • Contact: Ya MIAO E-mail:linyijia2020@126.com;nning-my@163.com
  • Supported by:
    Natural Science Foundation of Shanghai(19ZR1438800)

摘要:

阿尔茨海默病(Alzheimer's disease,AD)是一种神经退行性疾病,也是老年痴呆的主要类型之一。近年来的研究发现,AD患者常发生线粒体自噬异常。相关研究显示,线粒体自噬是线粒体质量和数量控制的重要途径,即细胞可通过选择性自噬清除受损或功能失调的线粒体,以维持细胞的正常生理功能和能量供应。该文从AD状态下线粒体自噬发生的异常变化及该变化在AD发生发展中的作用及机制进行综述,以期提供通过靶向诱导线粒体自噬来控制并延缓AD进程的新思路。

关键词: 阿尔茨海默病, 线粒体自噬, 线粒体

Abstract:

Alzheimer's disease (AD) is a neurodegenerative disease and one of the main types of senile dementia. In recent years, abnormal mitophagy often occurs in AD patients. Relevant studies have shown that mitophagy is an important way to control the quality and quantity of mitochondria, that is, cells can remove damaged or dysfunctional mitochondria through selective autophagy to maintain the normal physiological function and energy supply. This article reviews the abnormal changes of mitophagy in AD and its role and mechanism in the occurrence and development of AD, in order to offer new ideas for controlling and delaying the process of AD by targeted induction of mitophagy.

Key words: Alzheimer's disease (AD), mitophagy, mitochondria

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