上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (2): 165-.

• 专题报道（妇科疾病研究） • 上一篇    下一篇

妊娠晚期盆底功能障碍与血清松驰素H2质量浓度和阴道壁松驰素受体LGR7 mRNA表达的关系

姜 丽, 吴氢凯, 罗来敏, 冯 洁   

  1. 上海交通大学 第六人民医院妇产科, 上海 200233
  • 出版日期:2010-02-25 发布日期:2010-02-25
  • 通讯作者: 吴氢凯, 电子信箱: angelh2@163.com。
  • 作者简介:姜丽（1977—）, 女, 主治医师, 硕士；电子信箱: lijiang36@126.com。
  • 基金资助:

    上海市卫生局基金（2006057）

Relationship between pelvic floor dysfunction and serum relaxin H2 and expression of vaginal wall relaxin receptor LGR7 mRNA in late pregnant women

JIANG Li, WU Qing-kai, LUO Lai-min, FENG Jie   

  1. Department of Obstetrics and Gynecology, The Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2010-02-25 Published:2010-02-25
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 2006057

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摘要：

目的 探讨妊娠晚期盆底功能障碍与血清松弛素H2质量浓度及阴道壁松弛素受体LGR7 mRNA表达水平的关系。方法根据临产前盆底器官脱垂定量分度（POP-Q）评分，选择阴道前壁脱垂Ⅱ度合并压力性尿失禁的头位初产孕妇为病例组（n=12）；无压力性尿失禁及盆底器官脱垂的妊娠晚期孕妇为对照组（n=24）。ELISA法检测血清松弛素H2浓度；阴道分娩后取会阴侧切处阴道壁组织行RT-PCR，检测松弛素受体LGR7 mRNA的表达。结果 病例组血清松弛素H2的浓度和阴道壁组织LGR7 mRNA的表达水平均高于对照组，差异有统计学意义（P<0.01和P<0.05)。结论 妊娠晚期盆底功能障碍的发生可能与血清松弛素水平升高及阴道壁松弛素受体表达增加有关。

关键词: 妊娠, 盆底功能障碍, 松弛素, 松弛素受体LGR7

Abstract:

Objective To investigate the relationship between pelvic floor dysfunction and serum relaxin H2 and expression of vaginal wall relaxin receptor LGR7 mRNA in late pregnant women. Methods Before the beginning of delivery, all women were evaluated by pelvic organ prolapse quantitation (POP-Q) scoring. Twelve women with stress urinary incontinence (SUI) and stage Ⅱ prolapse of anterior vaginal wall were selected as patient group, and another 24 women without SUI and prolapse of pelvic floor were served as control group. Serum relaxin H2 was determined by ELISA. Vaginal wall tissues were taken after vaginal delivery, and the expression of relaxin receptor LGR7 mRNA was detected by RT-PCR. Results The serum level of relaxin H2 and expression of LGR7 mRNA of vaginal tissues in patient group were significantly higher than those in control group (P<0.01, P<0.05). Conclusion The increased level of serum relaxin and expression of vaginal wall relaxin receptor may correlate with the pelvic floor dysfunction in late pregnant women.

Key words: pregnancy, pelvic floor dysfunction, relaxin, relaxin receptor LGR7