›› 2011, Vol. 31 ›› Issue (7): 1022-.doi: 10.3969/j.issn.1674-8115.2011.07.034

• 综述 • 上一篇    下一篇

长非编码RNA与其他表观遗传机制在肿瘤中的相互调控

孙甜甜, 房静远   

  1. 上海交通大学 医学院附属仁济医院 上海市消化疾病研究所, 上海 200001
  • 出版日期:2011-07-28 发布日期:2011-07-27
  • 通讯作者: 房静远, 电子信箱: jingyuanfang@yahoo.com。
  • 作者简介:孙甜甜(1986—), 女, 硕士生;电子信箱: suntt2005@126.com。

Interaction of long noncoding RNAs and other epigenetic mechanisms in tumors

SUN Tian-tian, FANG Jing-yuan   

  1. Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Disease, Shanghai 200001, China
  • Online:2011-07-28 Published:2011-07-27

摘要:

长非编码RNA(lncRNA)是新发现的RNA干扰方式,与其他包括DNA甲基化、组蛋白修饰、染色质重构等表观遗传形式一样,在恶性肿瘤的发生和发展中起着重要作用。近年分子肿瘤学研究显示,lncRNA与其他表观遗传形式相互作用,如lncRNA可通过多种途径调控DNA甲基化、组蛋白修饰、染色质重构和其他RNA干扰形式,而DNA甲基化、染色质重构等也可调控lncRNA的表达及作用;其错综复杂的网路关系影响肿瘤的发生和发展。

关键词: 长非编码RNA, 表观遗传, 肿瘤

Abstract:

As a newly discovered RNA interference method, long noncoding RNAs (lncRNA) play an important role in the development and progression of carcinomas, just as other epigenetic mechanisms including DNA methylation, histone modifications and chromatin remodeling. Recent researches have highlighted that lncRNA can interact with other epigenetic mechanisms. lncRNA can regulate DNA methylation, histone modifications, chromatin remodeling and other RNA interference through many ways, and the expression and role of lncRNA can be regulated by DNA methylation and chromatin remodeling. The complex relationship affects the development and progression of carcinomas.

Key words: long noncoding RNAs, epigenetics, tumor