上海交通大学学报（医学版）

›› 2013, Vol. 33 ›› Issue (3): 368-.doi: 10.3969/j.issn.1674-8115.2013.03.023

• 综述 • 上一篇    下一篇

噬菌体裂解酶作为抗菌药物的研究进展

王 铮1, 沈文彬1, 张浩天1, 么 娆1, 崔泽林2, 何 平2   

  1. 1.上海交通大学 医学院临床医学专业八年制2009级, 上海 200025； 2.上海交通大学 基础医学院病原生物学教研室, 上海 200025
  • 出版日期:2013-03-28 发布日期:2013-03-29
  • 通讯作者: 何 平, 电子信箱: hpatsh@sjtu.edu.cn。
  • 作者简介:王 铮（1990—）, 男, 本科生； 电子信箱: ricow@foxmail.com。

Prospects of bacteriophage endolysins as antibacterial agents

WANG Zheng1, SHEN Wen-bin1, ZHANG Hao-tian1, YAO Rao1, CUI Ze-lin2, HE Ping2   

  1. 1.Grade 2009 of the 8-year Medical Education Program, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China； 2.Department of Medical Microbiology and Parasitology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
  • Online:2013-03-28 Published:2013-03-29

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摘要：

传统抗菌药物的耐药问题日益突出，促使人们开始寻求更好的新型抗菌物质。噬菌体裂解酶是由双链DNA噬菌体编码、依靠宿主菌合成的酶，其能特异、高效地水解细菌的细胞壁，使细菌裂解死亡。噬菌体裂解酶在体外及动物体内模型实验中显示出良好的杀菌作用，且至今尚无直接对人体产生毒性的报道，噬菌体裂解酶的特性使其在预防、治疗细菌感染方面拥有广阔的应用前景。

关键词: 噬菌体裂解酶, 抗菌药物, 耐药性

Abstract:

At present, there is an urgent need for better novel antibacterial agents due to the dramatic rise in antibiotic resistance among bacteria. Bacteriophage endolysins, encoded by dsDNA phages, synthesized by host bacteria, will result in bacteria death by inducing the lysis of bacteria cell wall specifically and effectively. Studies in vitro and in vivo have demonstrated that endolysins are possessed of strong bactericidal effect without any direct adverse effects, and have broad prospects of application in prophylaxis and treatment of bacterial infections. The prospects of bacteriophage endolysins as antibacterial agents are introduced in this article.

Key words: bacteriophage endolysins, antibacterial agents, bacterial resistance