上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (10): 1438-.doi: 10.3969/j.issn.1674-8115.2017.10.026

• 综述 • 上一篇    下一篇

TRIP-Br2 的生物学作用

佘新平，郑志   

  1. 上海交通大学附属第一人民医院 上海市眼底病重点实验室，上海市眼视觉及光医学工程研究中心，上海 200080
  • 出版日期:2017-10-28 发布日期:2017-11-01
  • 作者简介:佘新平（1992—），女，硕士生；电子信箱：18916903992@163.com
  • 基金资助:
     国家自然科学基金（81470643）

Biomedical effects of TRIP-Br2

SHE Xin-ping, ZHENG Zhi   

  1. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2017-10-28 Published:2017-11-01
  • Supported by:
    National Natural Science Foundation of China, 81470643

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摘要： TRIP-Br2 是一种细胞周期调节因子，能与DP-1 特异性结合，参与转录因子E2F-1/DP-1 介导的转录增殖活动，维持基因组 稳定性。在能量代谢方面，TRIP-Br2 作用于启动子E2F-1，抑制脂解作用，降低机体能量代谢率。TRIP-Br2 过度表达可激活E2F-1/ DP-1 介导的细胞周期调控，导致基因组稳定性下降，促进肿瘤的发生。同时，高水平的 TRIP-Br2 可诱导棕色脂肪细胞释放炎症因子 和急性期反应蛋白，产生炎症反应和急性相位反应。该文对 TRIP-Br2 的自身分子结构及其在增殖、代谢、炎症等过程中的生物学作 用进行综述。

关键词: &ensp, TRIP-Br2, 能量代谢, 肿瘤, 炎症

Abstract:

TRIP-Br2 (transcriptional regulator interacting with the PHD zinc finger and/or the bromodomain 2) is a kind of cell cycle regulator, which can specifically bind to transcription factor DP-1 (DRTF-1-polypeptide-1) and participate in E2F-1 (E2 factor-1)/DP-1-mediated transcriptional proliferative activities and maintain genome stability. As for energy metabolism, overexpression of TRIP-Br2 activates E2F-1/DP-1-mediated cell cycle regulation, leading to decreased genomic stability and promoting oncogenesis. High levels of TRIP-Br2 can induce brown adipocytes to release inflammatory factors and acute phase response proteins, producing inflammatory responses and acute phase responses. This paper summarizes the molecular structure of TRIPBr2 and its biological role in proliferation, metabolism, and inflammation.

Key words: TRIP-Br2, energy metabolism, neoplasm, inflammation