上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (6): 842-.doi: 10.3969/j.issn.1674-8115.2017.06.022

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蛋白质精氨酸甲基转移酶在肿瘤中的作用及机制研究进展

文君，闵雪洁，赵丽，赵小平   

  1. 上海交通大学 医学院附属仁济医院核医学科，上海 200127
  • 出版日期:2017-06-28 发布日期:2017-07-05
  • 通讯作者: 赵小平，电子信箱：Zxp0856@sina.com
  • 作者简介:文君（1993—），女，硕士生；电子信箱：nyfcwenjun@163.com
  • 基金资助:

    国家自然科学基金（81372195，81572719）；上海市教育委员会高峰高原学科建设计划（20152516）

Research progress of effect and mechanism of protein arginine methyltransferase in tumors

WEN Jun, MIN Xue-jie, ZHAO Li, ZHAO Xiao-ping   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    National Natural Science Foundation of China, 81372195, 81572719; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152516

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摘要：

蛋白质精氨酸甲基转移酶(PRMT) 能甲基化多种蛋白，包括组蛋白和非组蛋白，影响多种细胞过程，如转录、RNA 剪接、 DNA 修复、细胞周期的控制等。PRMT 的活性受多种调节机制影响，它的异常表达在疾病的发生发展中起重要作用，尤其是肿瘤， 如乳腺癌、白血病等。PRMT 在肿瘤诊断或治疗中有着独特的价值。随着 PRMT 甲基化机制的深入探索，目前 PRMT 选择性抑制剂 的研究已取得一定进展，PRMT 特异性抑制剂有望成为治疗肿瘤的精准靶向药物。

关键词: 蛋白质精氨酸甲基转移酶, 甲基化, 肿瘤

Abstract:

 Protein arginine methyltransferase (PRMT) can methylate a variety of proteins, including histones and non-histones, affecting a variety of cellular processes such as transcription, RNA splicing, DNA repair, and cell cycle control. The activity of PRMT is affected by a variety of regulatory mechanisms, and its abnormal expression plays an important role in the development of the diseases, especially in tumors such as breast cancer and leukemia. PRMT has a unique value in the diagnosis or treatment of tumors. With the further exploration of PRMT methylation mechanism, PRMT selective inhibitors have made some progress. PRMT-specific inhibitors are expected to be targeted drugs for the treatment of tumors.

Key words: PRMT, methylation, tumor