上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (6): 836-.doi: 10.3969/j.issn.1674-8115.2017.06.021

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动脉粥样硬化免疫治疗的临床研究进展

尤纱纱，曹惠敏，薛晓梅，何斌   

  1. 上海交通大学 医学院附属新华医院麻醉与重症医学科，上海 200092
  • 出版日期:2017-06-28 发布日期:2017-07-05
  • 通讯作者: ?何斌，电子信箱：hebin@xinhuamed.com.cn
  • 作者简介:尤纱纱（1992—），女，硕士生；电子信箱：yokia_youshasha@163.com
  • 基金资助:

    国家自然科学基金（81470390）；上海市教育委员会高峰高原学科建设计划（20152218）

Clinical research progress in immunotherapy against atherosclerosis

YOU Sha-sha, CAO Hui-min, XUE Xiao-mei, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    National Natural Science Foundation of China, 81470390; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152218）

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摘要：

动脉粥样硬化是机体免疫系统对内源性或外源性抗原产生免疫应答引起的动脉内膜的慢性炎症性疾病，固有免疫和特异性免 疫皆发挥不可或缺的作用。近些年研究表明，通过某些自身抗原或外源性抗原诱导动物产生保护性免疫应答可以缓解动脉粥样硬化， 且一些临床试验发现动脉粥样硬化及冠状动脉粥样硬化性心脏病与体内免疫细胞、免疫因子的存在有关。因此，免疫疗法有望成为动 脉粥样硬化新的防治措施。该文对近些年动脉粥样硬化的免疫机制研究及相关免疫治疗的研究进展进行综述。

关键词: 动脉粥样硬化, 被动免疫, 疫苗, 低密度脂蛋白

Abstract:

 Atherosclerosis is a chronic inflammatory disease, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Subsequent investigations have revealed that an immunomodulatory strategy via active immunization against atherosclerotic plaque antigen(s) could potentially alleviate atherosclerosis. Substantial data from clinical investigations support the key role of immune system in atherosclerosis. So, it may be promising to develop immunotherapy against atherosclerosis. The paper reviews current status of immunization studies and possible associated immunemediated inflammatory mechanisms in atherosclerosis.

Key words: atherosclerosis, passive immunization;, vaccine, low-density lipoprotein