上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2017, Vol. 37 ›› Issue (6): 865-.doi: 10.3969/j.issn.1674-8115.2017.06.026

• 综述 • 上一篇    下一篇

转录因子 C/EBPβ在子宫蜕膜化中的作用及机制研究进展

狄芳芳，刘建胜，李尚，杜艳芝   

  1. 上海交通大学 医学院附属仁济医院生殖医学中心，上海市辅助生殖与优生重点实验室，上海 200135
  • 出版日期:2017-06-28 发布日期:2017-07-05
  • 通讯作者: 杜艳芝，电子信箱：yanzhidu@hotmail.com
  • 作者简介:狄芳芳（1991—），女，硕士生；电子信箱：dfffang@163.com
  • 基金资助:

    上海市教育委员会高峰高原学科建设计划（20152510）

Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization

DI Fang-fang, LIU Jian-sheng, LI Shang, DU Yan-zhi   

  1. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152510

PDF (PC)

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摘要：

 CCAAT 增强子结合蛋白 β（C/EBPβ）是 CCAAT 增强子结合蛋白家族的重要成员。C/EBPβ蛋白可通过其羧基端 bZIP 结构域调控 下游靶基因的转录活性，进而参与细胞的增殖、分化等生命活动。近期研究显示，C/EBPβ在子宫内膜基质细胞的蜕膜化过程中具有重要 的调控作用。该文就近年来 C/EBPβ在子宫内膜基质细胞蜕膜化中的作用及机制进行综述，旨在为临床蜕膜化障碍研究提供新的视角。

关键词: &ensp, CCAAT 增强子结合蛋白 &beta, 子宫内膜基质细胞, 蜕膜化, 增殖, 分化, 细胞周期

Abstract:

 CCAAT/enhancer binding protein β (C/EBPβ) is a critical member of C/EBP family. C/EBPβ, based on the leucine zipper located in C terminal of the protein, can regulate transcriptional activities of downstream target genes involved in diverse cellular processes, such as proliferation and differentiation. Recently published studies have identified that C/EBPβ is essential in the decidualization of endometrial stromal cells. This review summarizes the roles and mechanisms of C/EBPβ during the courses of decidualization, which is aimed at providing novel insights for dysfunctional decidualization.

Key words: CCAAT/enhancer binding protein β, endometrial stromal cell, decidualization, proliferation, differentiation, cell cycle