上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (1): 1-.doi: 10.3969/j.issn.1674-8115.2018.01.001

• 述评 中国卓越国际论文 • 上一篇    下一篇

组蛋白修饰与胶质瘤发生发展

尽管组蛋白修饰的表观遗传学调控作用受到越来越多的关注，但其具体调控机制尚未明确。该文主要介绍组蛋白H3K23 乙酰化修饰在胶质瘤发生发展中的作用，并进一步阐明H3K23 乙酰化调控胶质瘤发生发展的新机制。该机制的揭示有望为胶质瘤治疗提供新思路。   

  1. 上海交通大学 医学院附属仁济医院仁济-Med X 临床干细胞研究中心
  • 出版日期:2018-01-28 发布日期:2018-03-09
  • 通讯作者: 冯海忠（1975—），男，研究员，博士；电子信箱：fenghaizhong@sjtu.edu.cn。
  • 作者简介:冯海忠（1975—），男，研究员，博士；电子信箱：fenghaizhong@sjtu.edu.cn
  • 基金资助:
    国家自然科学基金（81372704，81572467）；上海高校特聘教授（东方学者）岗位计划（2014024）；上海市教育委员会高峰高原学科建设计划
    （20161310）；上海市卫生和计划生育委员会优秀学科带头人“新百人”（2017BR021）

Histone modification and glioma tumorigenesis

Although epigenetic regulation of histone modification has attracted more and more attention, the underlying mechanisms are still unclear. The present review introduces the role of acetylated H3 lysine 23 (H3K23ac) in glioma tumorigenesis, and demonstrates a new mechanism by which H3K23ac regulates gliomagenesis, which may provide novel approaches to glioma treatment.   

  1. Renji-Med X Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
    National Natural Science Foundation of China, 81372704, 81572467; Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, 2014024; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support, 20161310; New Hundred Talent Program (Outstanding Academic Leader) at Shanghai Municipal Health Bureau, 2017BR021

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摘要： 尽管组蛋白修饰的表观遗传学调控作用受到越来越多的关注，但其具体调控机制尚未明确。该文主要介绍组蛋白H3K23 乙酰化修饰在胶质瘤发生发展中的作用，并进一步阐明H3K23 乙酰化调控胶质瘤发生发展的新机制。该机制的揭示有望为胶质瘤治疗提供新思路。

关键词: 组蛋白修饰, 胶质瘤, 乙酰化

Abstract:

Although epigenetic regulation of histone modification has attracted more and more attention, the underlying mechanisms are still unclear. The
present review introduces the role of acetylated H3 lysine 23 (H3K23ac) in glioma tumorigenesis, and demonstrates a new mechanism by which H3K23ac
regulates gliomagenesis, which may provide novel approaches to glioma treatment.

Key words: histone modification, glioma, acetylation