上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (4): 472-.doi: 10.3969/j.issn.1674-8115.2018.04.023

• 综述 • 上一篇    下一篇

BV8及其抗体与血管新生的关系

刘进权1，谢冰2   

  1. 上海交通大学医学院 1.瑞金临床医学院，2. 附属瑞金医院眼科，上海200025
  • 出版日期:2018-04-28 发布日期:2018-05-03
  • 通讯作者: 谢冰，电子信箱：brinkleybing@hotmail.com。
  • 作者简介:刘进权（1993—），男，学士，电子信箱：liujinquan2017@126.com。
  • 基金资助:
    国家自然科学基金（81570853）

Role of BV8 and its antibody in angiogenesis

LIU Jin-quan1, XIE Bing2   

  1. 1. Clinic Medical College, 2.Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    National Natural Science Foundation of China, 81570853

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摘要： BV8作为一种新发现的分泌蛋白，在内分泌腺、心血管、肾脏等器官血管新生中发挥重要作用，尤其与CD11b+Gr1+髓样细胞相关的肿瘤血管新生和发展密切相关。同时，动物模型研究证实，抗BV8抗体能明显抑制肿瘤中新生血管形成，从而起到显著的抗实体肿瘤作用。该综述对BV8的结构、功能、机制及其在疾病中的作用进行了系统回顾，以期为恶性肿瘤抗血管疗法新靶点的开发及后续BV8的研究提供新的思路和方向。

关键词: BV8, 新生血管, 肿瘤血管化, 抗肿瘤

Abstract:

BV8, a lately defined secreted protein, is proved to play an important role in the angiogenesis process of endocrine, cardiovascular system, kidney and other organs. Moreover, it contributes to the CD11b+Gr1+ myeloid cell-dependent tumor neo-vascularization. Meanwhile, anti-BV8 antibodytherapy has been shown to be against solid tumors via inhibition of angiogenesis in animal models. This review systematically introduced the currentknowledge on BV8 structure to function, mechanism to its role in diseases. Consequently, this review will probably provide new ideas anddirection to the new target of the current anti-vascular therapy for cancer and to the future investigation.

Key words: BV8, angiogenesis, tumor angiogenesis, antineoplastic

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