上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2018, Vol. 38 ›› Issue (8): 990-.doi: 10.3969/j.issn.1674-8115.2018.08.022

• 综述 • 上一篇    下一篇

阴道菌群失衡对女性生育力影响的研究进展

储维薇，徐洁颖，陈子江，杜艳芝   

  1. 上海交通大学医学院附属仁济医院生殖医学中心，上海市辅助生殖与优生重点实验室，上海 200135
  • 出版日期:2018-08-28 发布日期:2018-09-11
  • 通讯作者: 杜艳芝，电子信箱：duyz@sjtu.edu.cn。
  • 作者简介:储维薇（1993—），女，硕士生；电子信箱： weiweichu1993@hotmail.com。
  • 基金资助:
    国家自然科学基金（ 81671414）；上海市教育委员会高峰高原学科建设计划（ 20152510）

Effect of imblanced vaginal flora on female infertility

CHU Wei-wei, XU Jie-ying, CHEN Zi-jiang, DU Yan-zhi   

  1. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China
  • Online:2018-08-28 Published:2018-09-11
  • Supported by:
    National Natural Science Foundation of China, 81671414; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20152510

PDF (PC)

642

摘要： 近年来不孕症的发病率不断上升，其病因的多样性和复杂性给临床诊治带来一定难度。阴道菌群与宿主之间的相互作用对维持女性生理功能至关重要，阴道菌群紊乱与输卵管性不孕、子宫内膜异位症性不孕、无排卵性不孕、特发性不孕等均存在相关性。阴道菌群紊乱在女性不孕症的发生、发展过程中可能发挥一定作用，但目前具体作用机制尚不明确，其可能与乳酸杆菌缺失、慢性炎症反应、体内激素水平紊乱等有关，仍需进一步深入研究。

关键词: 阴道菌群, 不孕症, 细菌性阴道病, 炎症

Abstract:

Recently the incidence of female infertility is on the rise. The variable and complicated caof infertility makes it difficult to diagnose in clinical practise. The relationship between vaginal flora and host immune system plays a vital role in female physiological function. Vaginal microbiota dysbiosis may be related to all kinds of infertility, such as tube infertility, endometriosis, anovulatory infertility and idiopathic infertility. In other words, vaginal microbiota dysbiosis may take part in the infertile process. For now the mechanism is far clear. Some scientists suppose that Lactobacillus deficiency, chronic inflamationandlow estrogen levelmight get involved inthispathophysiological progression,which needs to be studied in the furture.

Key words: vaginal microbiota, femaleinfertility, bacterialvaginosis, inflammation

中图分类号: