非经典Wnt通路在卵巢癌中的作用与潜在治疗意义研究进展

doi:10.3969/j.issn.1674-8115.2023.08.015

摘要/Abstract

摘要：

卵巢癌是病死率最高的女性生殖系统恶性肿瘤，其发生发展过程涉及多种信号通路的异常调控。Wnt信号通路是一种高度保守的分子信号通路，在胚胎发育、组织稳态以及肿瘤发生发展等生理及病理过程中发挥重要作用。Wnt信号通路包括经典的Wnt/β-连环蛋白（β-catenin）通路以及不依赖β-catenin转录活性的非经典Wnt通路，后者主要包括Wnt/平面细胞极性（Wnt/planar cell polarity，Wnt/PCP）通路和Wnt/Ca²⁺通路。以往研究主要集中于经典Wnt通路与肿瘤进展的关系，但近年来非经典Wnt通路逐渐受到重视，相关研究丰富了其在组织发育及肿瘤发生等生理及病理过程中的认知。现有研究提示，非经典Wnt通路在卵巢癌中受到异常调控，并与卵巢癌的分期及预后密切相关。非经典Wnt通路在卵巢癌细胞增殖、迁移、侵袭等多种生物学过程发挥重要作用，且该通路的变化与卵巢癌化学治疗（化疗）耐药也具有一定相关性。该文从上述多个角度对非经典Wnt通路在卵巢癌中的作用进行综述，并讨论基于非经典Wnt通路的卵巢癌靶向治疗研究进展，为开发新型靶向药物提供新的思路。

关键词: 卵巢癌, 非经典Wnt通路, 肿瘤进展, 化疗耐药, 靶向治疗

Abstract:

Ovarian cancer is a malignant tumor of the female reproductive system with the highest mortality, and involves the aberrant regulation of multiple molecular signaling pathways. As a highly conserved molecular pathway, Wnt signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumorigenesis. Wnt signaling pathway includes canonical Wnt/β-catenin pathway and non-canonical pathway, and the latter mainly includes Wnt/planar cell polarity (Wnt/PCP) pathway and Wnt/Ca²⁺ pathway. Previous studies have mainly focused on the relationship between the canonical Wnt pathway and tumor progression. Recently, the non-canonical Wnt pathway has gradually received attention, and related researches have enriched the understanding of the non-canonical Wnt pathway in physiological and pathological processes such as tissue development and tumorigenesis. The existing studies suggest that the nonclassical Wnt pathway is abnormally regulated in ovarian cancer and is closely related to the staging and prognosis of ovarian cancer. Non-classical Wnt pathway plays an important role in many biological processes such as proliferation, migration and invasion of ovarian cancer cells, and the changes of this pathway are also related to chemotherapy resistance of ovarian cancer. This article reviews the role of the non-canonical Wnt pathway in ovarian cancer, and discusses the research progress of targeted therapy based on the non-canonical Wnt pathway, aiming to provide new ideas for the development of novel targeted drugs.

Key words: ovarian cancer, non-canonical Wnt pathway, cancer progression, chemotherapy resistance, targeted therapy

中图分类号:

R737.31

周婉桢, 滕银成. 非经典Wnt通路在卵巢癌中的作用与潜在治疗意义研究进展[J]. 上海交通大学学报（医学版）, 2023, 43(8): 1056-1063.

ZHOU Wanzhen, TENG Yincheng. Research progress of the role of non-canonical Wnt signaling pathway in ovarian cancer and its potential therapeutic implications[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(8): 1056-1063.

图/表 1

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