
上海交通大学学报(医学版) ›› 2023, Vol. 43 ›› Issue (9): 1201-1210.doi: 10.3969/j.issn.1674-8115.2023.09.015
罗晨1,2(
), 沈玲1(
), 王传伟3, 顾佳妮4, 王瑾5, 赵黎1, 黄帅1
收稿日期:2023-01-29
接受日期:2023-05-23
出版日期:2023-09-28
发布日期:2023-09-28
通讯作者:
沈 玲,电子信箱:shenling@xinhuamed.com.cn。作者简介:罗 晨(1997—),女,护士,硕士生;电子信箱:Luo.CH@sjtu.edu.cn。
基金资助:
LUO Chen1,2(
), SHEN Ling1(
), WANG Chuanwei3, GU Jiani4, WANG Jin5, ZHAO Li1, HUANG Shuai1
Received:2023-01-29
Accepted:2023-05-23
Online:2023-09-28
Published:2023-09-28
Contact:
SHEN Ling, E-mail: shenling@xinhuamed.com.cn.Supported by:摘要:
目的·了解腹腔镜结直肠癌(colorectal cancer,CRC)根治术后患者早期下床活动现状及其影响因素。方法·采用方便抽样法,选取2022年1月—12月入住上海交通大学医学院附属新华医院肛肠外科和普外科的腹腔镜CRC根治术后患者作为研究对象,于术后24 h、48 h、72 h采用床旁询问患者和查看电子病历系统的方式收集患者的一般资料,疾病、手术、术后相关资料以及术后下床活动情况。采用单因素分析和二元Logistic回归进行影响因素分析。结果·共纳入277例患者,术后24 h内有47例患者下床活动,早期下床活动率仅为16.97%;这47例患者术后24 h内的步行距离为55.46(18.28,145.60)m,最小距离2.60 m,最大距离803.68 m。术后24 h内、>24~48 h、>48~72 h的Brown平均下床活动评分分别为2(0,4)分、8(0,10)分、8(8,10)分,分别属于低活动水平、中等活动水平、中等活动水平。早期下床组与未早期下床组患者的年龄、术前血红蛋白水平、麻醉时长、留置导管数目的差异有统计学意义(均P<0.05)。与未早期下床组相比,早期下床组患者首次排气时间、首次排便时间、术后住院时间均较短,差异具有统计学意义(均P<0.05)。早期下床组术后未发生并发症,未早期下床组术后有11例患者发生并发症,并发症发生率为4.78%。二元Logistic回归分析显示,年龄≥70岁、术前血红蛋白水平低、麻醉时长长是患者术后早期下床活动的独立危险因素(均P<0.05)。结论·腹腔镜CRC根治术后患者早期下床活动可显著加快术后康复,但患者早期下床活动现况有待改善。年龄、术前血红蛋白水平、麻醉时长是患者术后早期下床活动的影响因素。
中图分类号:
罗晨, 沈玲, 王传伟, 顾佳妮, 王瑾, 赵黎, 黄帅. 腹腔镜结直肠癌根治术后患者早期下床活动现状及影响因素[J]. 上海交通大学学报(医学版), 2023, 43(9): 1201-1210.
LUO Chen, SHEN Ling, WANG Chuanwei, GU Jiani, WANG Jin, ZHAO Li, HUANG Shuai. Current status and influencing factors of early mobilization of patients undergoing laparoscopic radical resection of colorectal cancer[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(9): 1201-1210.
| Item | Within 24 h after surgery | Within >24‒48 h after surgery | Within >48‒72 h after surgery |
|---|---|---|---|
| Mobility/n(%) | 47 (16.97) | 167 (60.29) | 216 (77.98) |
| Walking distance/m | 55.46 (18.28, 145.60) | 138.48 (37.20, 307.88) | 169.62 (61.81, 395.57) |
| Minimum walking distance/m | 2.60 | 2.24 | 1.12 |
| Maximum walking distance/m | 803.68 | 2 040.92 | 5 302.80 |
| Brown rating of mobility/point | 2 (0, 4) | 8 (0, 10) | 8 (8, 10) |
| Brown level of mobility | Low | Moderate | Moderate |
表1 术后72 h内下床活动情况
Tab 1 Situation of mobilization within 72 h after surgery
| Item | Within 24 h after surgery | Within >24‒48 h after surgery | Within >48‒72 h after surgery |
|---|---|---|---|
| Mobility/n(%) | 47 (16.97) | 167 (60.29) | 216 (77.98) |
| Walking distance/m | 55.46 (18.28, 145.60) | 138.48 (37.20, 307.88) | 169.62 (61.81, 395.57) |
| Minimum walking distance/m | 2.60 | 2.24 | 1.12 |
| Maximum walking distance/m | 803.68 | 2 040.92 | 5 302.80 |
| Brown rating of mobility/point | 2 (0, 4) | 8 (0, 10) | 8 (8, 10) |
| Brown level of mobility | Low | Moderate | Moderate |
| Item | Non-early mobilization group (n=230) | Early mobilization group (n=47) | χ2/t value | P value |
|---|---|---|---|---|
| Gender/n(%) | 2.015 | 0.156 | ||
| Male | 136 (59.13) | 33 (70.21) | ||
| Female | 94 (40.87) | 14 (29.79) | ||
| Age/n(%) | 6.000 | 0.049 | ||
| <60 years old | 63 (27.39) | 21 (44.68) | ||
| 60‒69 years old | 96 (41.74) | 17 (36.17) | ||
| ≥70 years old | 71 (30.87) | 9 (19.15) | ||
| Education level/n(%) | 0.778 | 0.378 | ||
| Junior high school and below | 119 (51.74) | 21 (44.68) | ||
| Senior high school and above | 111 (48.26) | 26 (55.32) | ||
| Medical insurance payment method/n(%) | 1.595 | 0.451 | ||
| Urban medical insurance | 185 (80.43) | 34 (72.34) | ||
| Rural medical insurance | 37 (16.09) | 11 (23.40) | ||
| Self-payment | 8 (3.48) | 2 (4.26) | ||
| Marital status/n(%) | 2.120 | 0.548 | ||
| Married | 220 (95.65) | 47 (100.00) | ||
| Unmarried | 6 (2.61) | 0 (0) | ||
| Divorced | 2 (0.87) | 0 (0) | ||
| Widowed | 2 (0.87) | 0 (0) | ||
| Place of abode/n(%) | 0.398 | 0.528 | ||
| Town | 190 (82.61) | 37 (78.72) | ||
| Village | 40 (17.39) | 10 (21.28) | ||
| Underlying disease/n(%) | 0.049 | 0.825 | ||
| No | 89 (38.70) | 19 (40.43) | ||
| Yes | 141 (61.30) | 28 (59.57) | ||
| Preoperative NRS 2002 score/n (%) | 0.662 | 0.416 | ||
| <3 points | 209 (90.87) | 45 (95.74) | ||
| ≥3 points | 21 (9.13) | 2 (4.26) | ||
| Preoperative BMI/n(%) | 0.602 | 0.740 | ||
| <18.5 kg·m-2 | 17 (7.39) | 2 (4.26) | ||
| 18.5‒24.0 kg·m-2 | 132 (57.39) | 28 (59.57) | ||
| >24.0 kg·m-2 | 81 (35.22) | 17 (36.17) | ||
| Preoperative Hb level/n(%) | 4.594 | 0.032 | ||
| Low | 81 (35.22) | 9 (19.15) | ||
| Normal | 149 (64.78) | 38 (80.85) | ||
| Preoperative albumin level/n(%) | 0.854 | 0.355 | ||
| Low | 130 (56.52) | 30 (63.83) | ||
| Normal | 100 (43.48) | 17 (36.17) | ||
| Preoperative platelet level/(×109 L-1) | 217.61±76.89 | 215.47±60.11 | 0.180 | 0.857 |
| Cardiac function/n(%) | 0.116 | 0.943 | ||
| Ⅰ | 13 (5.65) | 3 (6.38) | ||
| Ⅱ | 189 (82.17) | 39 (82.98) | ||
| Ⅲ | 28 (12.17) | 5 (10.64) | ||
| ASA/n(%) | 0.620 | 0.734 | ||
| Ⅰ | 3 (1.30) | 0 (0) | ||
| Ⅱ | 87 (37.83) | 18 (38.30) | ||
| Ⅲ | 140 (60.87) | 29 (61.70) | ||
| Anesthesia duration/h | 3.73±0.95 | 3.36±0.92 | 2.601 | 0.010 |
| Number of indwelling catheters/n | 3.04±0.80 | 2.75±0.87 | 2.236 | 0.026 |
| Stopping ECG monitor within 24 h after surgery/n(%) | 1.557 | 0.212 | ||
| No | 20 (8.70) | 1 (2.13) | ||
| Yes | 210 (91.30) | 46 (97.87) | ||
| Stopping venous PCA within 24 h after surgery/n(%) | 2.404 | 0.121 | ||
| No | 189 (82.17) | 34 (72.34) | ||
| Yes | 41 (17.83) | 13 (27.66) | ||
| Nausea and vomiting within 24 h after surgery/n(%) | 1.123 | 0.289 | ||
| No | 169 (73.48) | 38 (80.85) | ||
| Yes | 61 (26.52) | 9 (19.15) | ||
| VAS within 24 h after surgery/point | 0.95±1.65 | 0.75±1.53 | 0.781 | 0.436 |
表2 未早期下床组与早期下床组相关资料比较
Tab 2 Comparison of relevant factors between the non-early mobilization group and the early mobilization group
| Item | Non-early mobilization group (n=230) | Early mobilization group (n=47) | χ2/t value | P value |
|---|---|---|---|---|
| Gender/n(%) | 2.015 | 0.156 | ||
| Male | 136 (59.13) | 33 (70.21) | ||
| Female | 94 (40.87) | 14 (29.79) | ||
| Age/n(%) | 6.000 | 0.049 | ||
| <60 years old | 63 (27.39) | 21 (44.68) | ||
| 60‒69 years old | 96 (41.74) | 17 (36.17) | ||
| ≥70 years old | 71 (30.87) | 9 (19.15) | ||
| Education level/n(%) | 0.778 | 0.378 | ||
| Junior high school and below | 119 (51.74) | 21 (44.68) | ||
| Senior high school and above | 111 (48.26) | 26 (55.32) | ||
| Medical insurance payment method/n(%) | 1.595 | 0.451 | ||
| Urban medical insurance | 185 (80.43) | 34 (72.34) | ||
| Rural medical insurance | 37 (16.09) | 11 (23.40) | ||
| Self-payment | 8 (3.48) | 2 (4.26) | ||
| Marital status/n(%) | 2.120 | 0.548 | ||
| Married | 220 (95.65) | 47 (100.00) | ||
| Unmarried | 6 (2.61) | 0 (0) | ||
| Divorced | 2 (0.87) | 0 (0) | ||
| Widowed | 2 (0.87) | 0 (0) | ||
| Place of abode/n(%) | 0.398 | 0.528 | ||
| Town | 190 (82.61) | 37 (78.72) | ||
| Village | 40 (17.39) | 10 (21.28) | ||
| Underlying disease/n(%) | 0.049 | 0.825 | ||
| No | 89 (38.70) | 19 (40.43) | ||
| Yes | 141 (61.30) | 28 (59.57) | ||
| Preoperative NRS 2002 score/n (%) | 0.662 | 0.416 | ||
| <3 points | 209 (90.87) | 45 (95.74) | ||
| ≥3 points | 21 (9.13) | 2 (4.26) | ||
| Preoperative BMI/n(%) | 0.602 | 0.740 | ||
| <18.5 kg·m-2 | 17 (7.39) | 2 (4.26) | ||
| 18.5‒24.0 kg·m-2 | 132 (57.39) | 28 (59.57) | ||
| >24.0 kg·m-2 | 81 (35.22) | 17 (36.17) | ||
| Preoperative Hb level/n(%) | 4.594 | 0.032 | ||
| Low | 81 (35.22) | 9 (19.15) | ||
| Normal | 149 (64.78) | 38 (80.85) | ||
| Preoperative albumin level/n(%) | 0.854 | 0.355 | ||
| Low | 130 (56.52) | 30 (63.83) | ||
| Normal | 100 (43.48) | 17 (36.17) | ||
| Preoperative platelet level/(×109 L-1) | 217.61±76.89 | 215.47±60.11 | 0.180 | 0.857 |
| Cardiac function/n(%) | 0.116 | 0.943 | ||
| Ⅰ | 13 (5.65) | 3 (6.38) | ||
| Ⅱ | 189 (82.17) | 39 (82.98) | ||
| Ⅲ | 28 (12.17) | 5 (10.64) | ||
| ASA/n(%) | 0.620 | 0.734 | ||
| Ⅰ | 3 (1.30) | 0 (0) | ||
| Ⅱ | 87 (37.83) | 18 (38.30) | ||
| Ⅲ | 140 (60.87) | 29 (61.70) | ||
| Anesthesia duration/h | 3.73±0.95 | 3.36±0.92 | 2.601 | 0.010 |
| Number of indwelling catheters/n | 3.04±0.80 | 2.75±0.87 | 2.236 | 0.026 |
| Stopping ECG monitor within 24 h after surgery/n(%) | 1.557 | 0.212 | ||
| No | 20 (8.70) | 1 (2.13) | ||
| Yes | 210 (91.30) | 46 (97.87) | ||
| Stopping venous PCA within 24 h after surgery/n(%) | 2.404 | 0.121 | ||
| No | 189 (82.17) | 34 (72.34) | ||
| Yes | 41 (17.83) | 13 (27.66) | ||
| Nausea and vomiting within 24 h after surgery/n(%) | 1.123 | 0.289 | ||
| No | 169 (73.48) | 38 (80.85) | ||
| Yes | 61 (26.52) | 9 (19.15) | ||
| VAS within 24 h after surgery/point | 0.95±1.65 | 0.75±1.53 | 0.781 | 0.436 |
| Postoperative recovery indicator | Non-early mobilization group (n=230) | Early mobilization group (n=47) | χ2 value | P value |
|---|---|---|---|---|
| Initial exhaust time/n(%) | 4.752 | 0.029 | ||
| <24 h | 49 (21.30) | 17 (36.17) | ||
| ≥24 h | 181 (78.70) | 30 (63.83) | ||
| Initial defecation time/n(%) | 3.809 | 0.049 | ||
| <72 h | 106 (46.09) | 29 (61.70) | ||
| ≥72 h | 124 (53.91) | 18 (38.30) | ||
| Postoperative length of stay/n(%) | 5.650 | 0.017 | ||
| ≤7 d | 15 (6.52) | 8 (17.02) | ||
| >7 d | 215 (93.48) | 39 (82.98) |
表3 未早期下床组与早期下床组术后恢复指标比较
Tab 3 Comparison of postoperative recovery indicators between the non-early mobilization group and the early mobilization group
| Postoperative recovery indicator | Non-early mobilization group (n=230) | Early mobilization group (n=47) | χ2 value | P value |
|---|---|---|---|---|
| Initial exhaust time/n(%) | 4.752 | 0.029 | ||
| <24 h | 49 (21.30) | 17 (36.17) | ||
| ≥24 h | 181 (78.70) | 30 (63.83) | ||
| Initial defecation time/n(%) | 3.809 | 0.049 | ||
| <72 h | 106 (46.09) | 29 (61.70) | ||
| ≥72 h | 124 (53.91) | 18 (38.30) | ||
| Postoperative length of stay/n(%) | 5.650 | 0.017 | ||
| ≤7 d | 15 (6.52) | 8 (17.02) | ||
| >7 d | 215 (93.48) | 39 (82.98) |
| Variable | Assignment instruction |
|---|---|
| Anesthesia duration | Original value |
| Number of indwelling catheters | Original value |
| Age | <60 years old=0; 60‒69 years old=1; ≥70 years old=2 |
| Preoperative Hb level | Low=0; Normal=1 |
表4 二元Logistic回归分析自变量赋值
Tab 4 Assignment of independent variables in binary Logistic regression analysis
| Variable | Assignment instruction |
|---|---|
| Anesthesia duration | Original value |
| Number of indwelling catheters | Original value |
| Age | <60 years old=0; 60‒69 years old=1; ≥70 years old=2 |
| Preoperative Hb level | Low=0; Normal=1 |
| Item | β | SE | Wald χ2 | P value | OR | 95%CI |
|---|---|---|---|---|---|---|
| Age (<60 years old) | - | - | 4.799 | 0.091 | - | - |
| Age (60‒69 years old) | -0.620 | 0.377 | 2.707 | 0.100 | 0.538 | 0.257‒1.126 |
| Age (≥70 years old) | -0.890 | 0.447 | 3.962 | 0.047 | 0.411 | 0.171‒0.986 |
| Preoperative Hb level (normal) | 0.871 | 0.412 | 4.462 | 0.035 | 2.389 | 1.065‒5.362 |
| Number of indwelling catheters | -0.371 | 0.216 | 2.960 | 0.085 | 0.690 | 0.452‒1.053 |
| Anesthesia duration | -0.394 | 0.192 | 4.221 | 0.040 | 0.674 | 0.463‒0.982 |
| Constant | 0.706 | 0.854 | 0.684 | 0.408 | 2.027 | - |
表5 术后早期下床活动影响因素的二元Logistic回归分析
Tab 5 Binary Logistic regression analysis of factors influencing getting out of bed within 24 h after surgery
| Item | β | SE | Wald χ2 | P value | OR | 95%CI |
|---|---|---|---|---|---|---|
| Age (<60 years old) | - | - | 4.799 | 0.091 | - | - |
| Age (60‒69 years old) | -0.620 | 0.377 | 2.707 | 0.100 | 0.538 | 0.257‒1.126 |
| Age (≥70 years old) | -0.890 | 0.447 | 3.962 | 0.047 | 0.411 | 0.171‒0.986 |
| Preoperative Hb level (normal) | 0.871 | 0.412 | 4.462 | 0.035 | 2.389 | 1.065‒5.362 |
| Number of indwelling catheters | -0.371 | 0.216 | 2.960 | 0.085 | 0.690 | 0.452‒1.053 |
| Anesthesia duration | -0.394 | 0.192 | 4.221 | 0.040 | 0.674 | 0.463‒0.982 |
| Constant | 0.706 | 0.854 | 0.684 | 0.408 | 2.027 | - |
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