
上海交通大学学报(医学版) ›› 2026, Vol. 46 ›› Issue (9): 1179-1187.doi: 10.3969/j.issn.1674-8115.2026.09.003
• 前沿述评 • 上一篇
张鑫1,2, 李丹1,3, 杨菊1,3, 邓科蕾4, 曹宏1,2,3,5(
)
收稿日期:2025-12-04
接受日期:2026-02-02
出版日期:2026-09-28
发布日期:2026-09-28
通讯作者:
曹 宏,教授,博士;电子信箱:hongcao@jiangnan.edu.cn。基金资助:
Zhang Xin1,2, Li Dan1,3, Yang Ju1,3, Deng Kelei4, Cao Hong1,2,3,5(
)
Received:2025-12-04
Accepted:2026-02-02
Online:2026-09-28
Published:2026-09-28
Contact:
Cao Hong, E-mail: hongcao@jiangnan.edu.cn.Supported by:摘要:
骨质疏松症以骨量丢失和微结构破坏为特征,已成为降低全球中老年人生活质量并加剧社会经济负担的系统性骨病。细胞外囊泡(extracellular vesicles,EVs)是细胞间信息传递的重要载体,内含蛋白质、脂质及核酸等多种活性分子,在骨重塑平衡中发挥关键作用。EVs既能推动成骨细胞分化,又能抑制破骨细胞活性,并刺激血管新生,因而在骨质疏松治疗中显示出潜力。然而,天然EVs在体内清除快、靶向弱等固有缺陷限制了其临床转化。为突破上述瓶颈,多种功能化策略相继出现。该文梳理EVs的基本特性与生物学行为,解析其在骨微环境中的多重调控机制;聚焦骨质疏松治疗新思路,探讨如何通过细胞预处理提升天然EVs活性,借助内容物工程和表面修饰增强工程化EVs的效能和靶向性,以及将后者与水凝胶或3D打印支架等智能材料耦合,构建可局部滞留、可控释放并协同促修复的递送体系;总结该领域面临的挑战,展望EVs用于骨质疏松精准治疗的前景,为开发高效、安全的无细胞骨再生疗法提供理论依据与研究视角。
中图分类号:
张鑫, 李丹, 杨菊, 邓科蕾, 曹宏. 细胞外囊泡在骨质疏松发生与治疗中的作用及其功能化递送策略[J]. 上海交通大学学报(医学版), 2026, 46(9): 1179-1187.
Zhang Xin, Li Dan, Yang Ju, Deng Kelei, Cao Hong. Roles of extracellular vesicles in pathogenesis and treatment of osteoporosis and their functionalized delivery strategies[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2026,(9): 1179-1187.
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