上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2013, Vol. 33 ›› Issue (6): 874-.doi: 10.3969/j.issn.1674-8115.2013.06.035

• 综述 • 上一篇    下一篇

自然绝经年龄相关候选基因的研究进展

孙东梅, 陶敏芳   

  1. 上海交通大学附属第六人民医院妇产科， 上海 200233
  • 出版日期:2013-06-28 发布日期:2013-06-28
  • 通讯作者: 陶敏芳, 电子信箱: taomf@126.com。
  • 作者简介:孙东梅（1986—）， 女， 硕士生; 电子信箱: sdcxsdm@163.com。

Research progress of candidate gene of age at natural menopause

SUN Dong-mei, TAO Min-fang   

  1. Department of Obstetrics and Gynecology, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China
  • Online:2013-06-28 Published:2013-06-28

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摘要：

自然绝经年龄（ANM）是受基因与环境共同影响的复杂性状，其中基因影响较为突出。绝经年龄的提前或延迟与女性相关疾病有关。探讨基因作用对ANM的影响，有助于预测绝经后女性潜在的健康问题，并可为女性提供相关的健康指导。目前，全基因组关联研究及候选基因关联分析已发现数个基因与之相关，该文就ANM相关基因的研究进展予以综述。

关键词: 自然绝经年龄, 候选基因, 单核苷酸多态性

Abstract:

Age at natural menopause (ANM) is a complex trait which is determined by genes and environment, and the genetic effects are prominent. Early or delayed menopause is associated with female-related diseases. Exploring genetic factors of ANM can help to predict the potential health problems of postmenopausal women, and may provide appropriate health guidance. It has been found by genome-wide association studies and candidate gene association studies that several genes are associated with ANM. The research progress of candidate genes of ANM is reviewed in this paper.

Key words: age at natural menopause, candidate gene, single nucleotide polymorphisms