上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2015, Vol. 35 ›› Issue (10): 1569-.doi: 10.3969/j.issn.1674-8115.2015.10.028

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精神分裂症认知损害动物模型的研究进展

林晔喆1，崔东红2   

  1. 1.上海交通大学 医学院附属精神卫生中心， 上海200030； 2.上海市重性精神病重点实验室， 上海201108
  • 出版日期:2015-10-20 发布日期:2015-12-22
  • 通讯作者: 崔东红, 电子信箱: manyucc@126.com
  • 作者简介:林晔喆（1991—）， 女， 硕士生; 电子信箱: yezhe.lin@foxmail.com
  • 基金资助:

    国家自然科学基金面上项目（81171266,81271481）；上海市科技创新基金（重点）计划（11140900400）；上海市重性精神疾病重点实验室（13dz2260500）

Research progresses of animal models of cognitive impairment of patients with schizophrenia

LIN Ye-zhe1, CUI Dong-hong2   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai200030, China; 2.Shanghai Key Laboratory of Psychotic Disorders, Shanghai201108, China
  • Online:2015-10-20 Published:2015-12-22
  • Supported by:

    National Nature Science Foundation of China, 81171266, 81271481; Project of Shanghai Science and Technology Innovation， 11140900400; Shanghai Key Laboratory of Psychotic Disorders, 13dz2260500

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摘要：

精神分裂症的认知损害以其对患者产生严重的社会功能影响而备受关注。现有治疗对于精神分裂症认知损害的改善效果不佳，需要针对这一问题进行大量的研究。因研究方法的限制，目前这方面的研究有限。动物模型，作为一种有效的研究工具，可以模拟精神分裂症患者的认知损害，以代替在人体无法直接进行的研究。文章总结了近年来利用实验动物模拟精神分裂症认知损害的研究进展，旨在为研究及改善精神分裂症的认知损害提供思路。

关键词: 精神分裂症, 认知损害, 动物模型

Abstract:

Cognitive impairment of patients with schizophrenia has attracted many attentions due to its severe effect on patients’ social function. The existing treatments of cognitive impairment of patients with schizophrenia are not effective and extensive researches are needed to solve this problem. However, due to limitations of research methods, researches of this area are limited. Animal models are effective tools that can mimic the cognitive impairment of patients with schizophrenia and complement the disadvantage that researches cannot be carried out on human beings. This paper reviews research progresses of mimicking the cognitive impairment of patients with schizophrenia by using laboratory animals and provides ideas for studying and alleviating the cognitive impairment of patients with schizophrenia.

Key words: schizophrenia, cognitive impairment, animal models