上海交通大学学报（医学版）

上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (1): 103-107.doi: 10.3969/j.issn.1674-8115.2021.01.019

• 综述 • 上一篇    下一篇

糖尿病肾病中的组蛋白修饰与靶向干预的研究进展

姜梦迪(), 张文()   

  1. 上海交通大学医学院附属瑞金医院肾脏内科，上海 200025
  • 出版日期:2021-01-28 发布日期:2021-02-22
  • 作者简介:姜梦迪（1993—），女，博士生；电子信箱：jmd1211@163.com。
  • 基金资助:
    国家自然科学基金(81670613)

Progress in histone modification and targeted intervention in diabetic nephropathy

Meng-di JIANG(), Wen ZHANG()   

  1. Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2021-01-28 Published:2021-02-22
  • Supported by:
    Funding Information] Funding Information National Natural Science Foundation of China(81670613)

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摘要：

糖尿病肾病致病机制复杂，临床治疗管理难度大。因“代谢记忆”的发现，表观遗传学在糖尿病肾病的研究中逐渐得到重视。糖尿病肾病的病理改变包括足细胞病变、系膜基质变化、上皮细胞-间充质转化等，其致病机制则涉及氧化应激、糖基化终产物、自噬与凋亡等过程。而作为糖尿病肾病发病机制中重要的组成部分，组蛋白乙酰化、甲基化、泛素化等修饰广泛参与以上过程。靶向组蛋白修饰的药物在实验条件下已取得较好的效果。该文针对糖尿病肾病发病过程中的组蛋白修饰与靶向干预的研究进展进行综述。

关键词: 糖尿病肾病, 组蛋白修饰, 表观遗传学, 代谢记忆, 组蛋白去乙酰化酶抑制剂

Abstract:

The management of diabetic nephropathy is grim, and its pathogenic mechanism is complicated. Epigenetics is gaining attention due to the discovery of "metabolic memory". Pathological changes of diabetic nephropathy include podocyte lesion, mesangial matrix change, epithelial-mesenchymal transition, etc. And its pathogenic mechanism involves processes such as oxidative stress, end-products of glycosylation, autophagy and apoptosis. As important parts of it, histone acetylation, methylation, ubiquitination and other modifications are widely involved in the above processes. Drugs targeting histone modification under experimental conditions have obtained positive results. This article reviews progresses of the histone modification and targeted treatment in the pathogenesis of diabetic nephropathy.

Key words: diabetic nephropathy, histone modification, epigenetics, metabolic memory, histone deacetylase inhibitor

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