上海交通大学学报（医学版）

上海交通大学学报（医学版） ›› 2023, Vol. 43 ›› Issue (7): 916-922.doi: 10.3969/j.issn.1674-8115.2023.07.014

• 综述 • 上一篇    

运动治疗抑郁障碍的研究进展

张硕渊1(), 李春波1,2()   

  1. 1.上海交通大学医学院附属精神卫生中心，上海市重性精神病重点实验室，上海 200030
    2.上海交通大学心理与行为科学研究院，上海 200030
  • 收稿日期:2023-03-02 接受日期:2023-06-25 出版日期:2023-07-28 发布日期:2023-07-28
  • 通讯作者: 李春波 E-mail:358302932@qq.com;licb@smhc.org.cn
  • 作者简介:张硕渊（1997—），男，硕士生；电子信箱：358302932@qq.com。
  • 基金资助:
    国家重点研发计划(2018YFC2001605);上海市精神心理临床医学研究中心(19MC1911100)

Research progress of exercise therapy for depressive disorder

ZHANG Shuoyuan1(), LI Chunbo1,2()   

  1. 1.Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Psychotic Disorders, Shanghai 200030, China
    2.Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai 200030, China
  • Received:2023-03-02 Accepted:2023-06-25 Online:2023-07-28 Published:2023-07-28
  • Contact: LI Chunbo E-mail:358302932@qq.com;licb@smhc.org.cn
  • Supported by:
    National Key R & D Program of China(2018YFC2001605);Clinical Research Center of Shanghai Mental Health Center(19MC1911100)

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摘要：

抑郁障碍作为全球的重大疾病之一，其预防与治疗方法备受关注。运动治疗作为新兴的治疗方式，相较于药物治疗和物理治疗等常规治疗方法，具有成本低、不良反应少且方便施行等优点，应用前景乐观。已有相关研究对运动治疗抑郁障碍的机制进行探索，但目前该机制并未明确，可能涉及提高神经生化分子水平、抑制炎症反应、调控神经内分泌系统以及改善神经可塑性等几个方面的影响。运动治疗被证明与抗抑郁药物存在相似的生物学效应，同时可能与其他治疗方法存在叠加效应。对未发病和已发病人群及早进行干预，都能使其在一定程度上获益。目前运动治疗抑郁障碍的相关临床领域仍存在空白，高质量研究甚少，运动治疗的方案设计仍处于探索阶段，尚未形成一致结论，且缺少相关的运动治疗指南供临床医师参考。该文综述了运动治疗抑郁障碍的生物学机制，总结国内外开展的运动治疗抑郁障碍的临床研究结果，分析目前运动治疗的方案设计和优缺点，以期为运动治疗研究领域的深入开展提供参考。

关键词: 抑郁障碍, 运动, 运动治疗, 干预

Abstract:

Depressive disorder, as one of the major diseases in the world, has always received much attention for its prevention and treatment. As an emerging treatment, exercise therapy has optimistic application prospect with the advantages such as lower cost, fewer side effects and easier implementation, compared to conventional treatments such as drug therapy and physical therapy. Relevant studies have explored the mechanism of exercise in the treatment of depressive disorder, but the mechanism is not clear yet, which may involve improving the levels of neurobiochemical molecules, inhibiting inflammatory response, regulating neuroendocrine system, improving neuroplasticity, and other aspects. Exercise therapy has been proved to have similar biological effects with antidepressants, and may have overlapping effects with other treatments. Early intervention can benefit both non- diseased and already diseased populations to a certain extent. At present, there is still a gap in the clinical field related to exercise therapy for depressive disorder, and there are few high-quality studies. The design of exercise therapy plans is still in the exploratory stage, and there is no consensus on the design of exercise therapy plans. Additionally, there is a lack of relevant exercise therapy guidelines for clinicians to refer to. This review systematically introduces the biological mechanism of exercise therapy for depressive disorder, summarizes the clinical research results in this field carried out at home and abroad, and analyzes the current program and advantages and disadvantages of exercise therapy, in order to provide reference for the in-depth development of the exercise therapy researches.

Key words: depressive disorder, exercise, exercise therapy, intervention

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