上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (8): 963-.

• 论著（临床研究） • 上一篇    下一篇

激素替代—冻融胚胎移植周期血清雌二醇监测的意义

牛志宏, 冯 云, 孙贻娟, 张慧琴, 张爱军   

  1. 上海交通大学 医学院瑞金医院生殖医学中心, 上海 200025
  • 出版日期:2009-08-25 发布日期:2009-09-27
  • 作者简介:牛志宏（1975—）, 女, 主治医师, 博士生；电子信箱: kangniu@sina.com。

Significance of serum estradiol monitoring in hormone replacement-frozen embryo transfer cycles

NIU Zhi-hong, FENG Yun, SUN Yi-juan, ZHANG Hui-qin, ZHANG Ai-jun   

  1. Reproductive Medical Center, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2009-08-25 Published:2009-09-27

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摘要：

目的 探讨激素替代—冻融胚胎移植周期中，血清雌激素水平对于胚胎移植时机的选择以及妊娠结局的影响。 方法 按照激素替代—冻融胚胎移植患者黄体酮开始注射日血清雌二醇质量浓度(pg/mL)的百分位数，将279个周期进行分组（组1百分位数为0～25，组2为26～75，组3为76～100）。组间比较促排卵周期和冻融胚胎移植周期的临床特征及妊娠结局；组间比较月经周期第2天、第12天和黄体酮开始注射日的血清雌二醇质量浓度和子宫内膜厚度。 结果 三组促排卵周期和冻融胚胎移植周期的相关特征及妊娠结局比较，差异均无统计学意义（P>0.05）；三组月经周期第2天、第12天和黄体酮开始注射日的子宫内膜厚度比较，差异均无统计学意义（P>0.05）。 结论 在非垂体降调节的激素替代—冻融胚胎移植中，黄体酮开始注射日的血清雌二醇水平对于子宫内膜厚度和妊娠结局无影响。

关键词: 雌二醇, 冻融胚胎移植, 妊娠, 子宫内膜

Abstract:

Objective To investigate the influence of serum estradiol level on timing of embryo transfer and pregnancy outcome in hormone replacement-frozen embryo transfer cycles. Methods According to the oestradiol level on progesterone initiation day, 279 hormone replacement-frozen embryo transfer cycles were grouped into three groups (group 1, percentile 0-25th; group 2, percentile 26th-75th; group 3, percentile 76th-100th). The clinical characteristics and pregnancy outcomes in ovarian stimulation cycles and frozen embryo transfer cycles were compared among groups, and the serum estradiol and endometrium thickness on day 2 and day 12 of menstrual cycle and progesterone initiation day were compared among groups. Results There was no significant difference in clinical characteristics and pregnancy outcomes in ovarian stimulation cycles and frozen embryo transfer cycles among three groups (P>0.05). There was no significant difference in endometrium thickness on day 2 and day 12 of menstrual cycle and progesterone initiation day among three groups (P>0.05). Conclusion The serum estradiol level on progesterone initiation day may not influence endometrium thickness and pregnancy outcomes in hormone replacement-frozen embryo transfer cycles without pituitary downregulation.

Key words: oestradiol, frozen embryo transfer, pregnancy, endometrium

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