上海交通大学学报（医学版）

›› 2009, Vol. 29 ›› Issue (12): 1450-.

• 论著（基础研究） • 上一篇    下一篇

STAT3、pSTAT3、VEGF和bFGF在非小细胞肺癌中的表达

王炯轶, 姜 斌, 刘 峰, 张文颖   

  1. 上海交通大学 医学院第三人民医院肿瘤科, 上海 201900
  • 出版日期:2009-12-25 发布日期:2009-12-25
  • 作者简介:王炯轶(1980—), 男, 硕士生；电子信箱: wangjiongyi@21cn.com。
  • 基金资助:

    上海市教委基金(08YZ47)

Expression of STAT3, pSTAT3, VEGF and bFGF in tissues of nonsmall-cell lung cancer

WANG Jiong-yi, JIANG Bin, LIU Feng, ZHANG Wen-ying   

  1. Department of Oncology, The Third People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201900, China
  • Online:2009-12-25 Published:2009-12-25
  • Supported by:

    Shanghai Education Committee Foundation, 08YZ47

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摘要：

目的 探讨信号转导及转录活化因子3 （STAT3）及其磷酸化形式pSTAT3与血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）在非小细胞肺癌(NSCLC)组织中的表达及关系。方法 应用免疫组织化学方法检测68例NSCLC和27例正常肺组织中STAT3、pSTAT3、VEGF、bFGF的表达，并分析其与各临床病理参数之间的关系。结果 STAT3、pSTAT3、VEGF、bFGF在NSCLC组织的阳性表达率均高于正常肺组织(P<0.05)；NSCLC中pSTAT3、VEGF、bFGF三者之间的表达呈正相关(P<0.05)。STAT3、pSTAT3在低分化NSCLC中的表达高于中、高分化者，在TNM Ⅲ+Ⅳ期NSCLC中的表达高于Ⅰ+Ⅱ期，有淋巴结转移者高于无淋巴结转移者，差异均有统计学意义（P<0.05)。VEGF、bFGF在TNM Ⅲ+Ⅳ期NSCLC中的表达高于Ⅰ+Ⅱ期（P<0.05)，有淋巴结转移者VEGF表达高于无淋巴结转移者 (P<0.05)。结论 STAT3、pSTAT3、VEGF和bFGF在非小细胞肺癌中高表达，并与肿瘤的侵袭和转移有关。

关键词: 非小细胞肺癌, 免疫组织化学, 信号转导及转录活化因子3, 血管内皮生长因子, 碱性成纤维细胞生长因子

Abstract:

Objective To investigate the expression of signal transducer and activator of transcription 3 (STAT3), phosphorylated STAT3 (pSTAT3), vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in tissues of nonsmall-cell lung cancer (NSCLC) and their relationship. Methods The expression of STAT3, pSTAT3, VEGF and bFGF in tissues of 68 cases of NSCLC and lung tissues of 27 normal cases were detected by immunohistochemistry methods, and their relationship with clinicopathological features was analyzed. Results The expression of STAT3, pSTAT3, VEGF and bFGF in tissues of NSCLC was significantly higher than that in normal lung tissues (P＜0.05). There was positive correlationship among pSTAT3,VEGF and bFGF in tissues of NSCLC (P＜0.05). The expression of STAT3 and pSTAT3 in NSCLC with poor differentiation was higher than that in NSCLC with high or moderate differentiation, the expression in NSCLC at TNM Ⅲ+Ⅳ stage was higher than that in NSCLC at TNMⅠ+Ⅱ stage, and the expression in NSCLC with lymph node metastasis was higher than that in NSCLC without lymph node metastasis(P<0.05). The expression of VEGF and bFGF in NSCLC at TNM Ⅲ+Ⅳ stage was higher than that in NSCLC at TNMⅠ+Ⅱ stage （P<0.05), and the expression of bFGF in NSCLC with lymph node metastasis was higher than that in NSCLC without lymph node metastasis （P<0.05). Conclusion STAT3,pSTAT3,VEGF and bFGF are highly expressed in NSCLC, and are involved in tumor metastasis and invasion.

Key words: nonsmall-cell lung cancer, immunohistochemistry, signal transducer and activator of transcription 3, vascular endothelial growth factor, basic fibroblast growth factor