上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (10): 1285-.doi: 10.3969/j.issn.1674-8115.2010.10.024

• 综述 • 上一篇    下一篇

NMDA受体与学习记忆关系的研究进展

李 强, 综述；薛庆生, 于布为, 审校   

  1. 上海交通大学 医学院附属瑞金医院麻醉科, 上海 200025
  • 出版日期:2010-10-25 发布日期:2010-10-27
  • 作者简介:李 强（1985—）, 男, 硕士生；电子信箱: tianhailiqiang@126.com。
  • 基金资助:

    国家自然科学基金（30400421, 30901410）

Research progress on relationship between NMDA receptors and learning and memory

LI Qiang, reviewer；XUE Qing-sheng, YU Bu-wei, reviser   

  1. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, |China
  • Online:2010-10-25 Published:2010-10-27
  • Supported by:

    National Natural Science Foundation of China, 30400421, 30901410

PDF (PC)

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摘要：

突触传递长时程增强（LTP）是神经元可塑性的反映，也是学习和记忆的神经生物学基础。目前，关于其形成机制的研究主要集中于N-甲基-D-天冬氨酸（NMDA）受体。三种不同亚基NR1、NR2、NR3组合成NMDAR，并在其功能中发挥不同作用。该文就NMDA受体在学习记忆机制中的作用作一综述。

关键词: N-甲基-D-天冬氨酸受体, 长时程增强, 学习, 记忆

Abstract:

Long-term potentiation (LTP) is thought to be a model for neuronal plasticity and the neuro-biochemical base of learning and memory. The studies of LTP molecular mechanism focus mainly on N-methyl-D-aspartate (NDMA) receptors. Various combinations of subunits including NR1, NR2, NR3 assemble to form NMDAR and generate diversity in its functions. The effects of NMDA receptors on learning and memory are reviewed in this paper.

Key words: N-methyl-D-aspartate receptor, long-term potentiation, learning, memory